DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7e and glr-5

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_505244.1	Gene:	glr-5 / 179251	WormBaseID:	WBGene00001616	Length:	932	Species:	Caenorhabditis elegans

Alignment Length:	468	Identity:	91/468 - (19%)
Similarity:	163/468 - (34%)	Gaps:	140/468 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 PFLTLDEDQEEVLRVNGGYEG---RLLLALAEKMNFTIAVRKVHVNMRDEAL--EMLRRDEVDLT 280
            |::.|.::..| |..|..:||   .||..|::.:.||..:..|    :|...  :.......|..
Worm   448 PYVMLKKNHYE-LDANSKFEGFCIDLLAELSKDLGFTYTIHAV----KDGKYGNDKYGNGSWDGM 507

  Fly   281 LGGIRQTVARGMVATSSHNYHQTREV-----FGVLASSY----------ELSSFDILFYPYRLQI 330
            :|.|.:..|...||..:.||.::..|     |..|..|.          :|.||   ..|...||
Worm   508 MGEILRGEAEMAVAPLTVNYRRSEAVDFTKPFLSLGISILYKVPDDQQPDLFSF---LNPLSWQI 569

  Fly   331 WMGILGVVALSALIQLIVGRMLRERMGSRFW-LNLELVFVGMPLLECPRSHTARLYC-------V 387
            |..|     .:::|.:.:|......:....| ||........|       |.|..:.       |
Worm   570 WTAI-----ATSIITVTLGMYFVANVTPYEWNLNFSCCTAHEP-------HPAAAFATNQEAPIV 622

  Fly   388 MLMMYTL------IIRTIYQG------------------LLYHLIRTHQLNRWPQTIESLVQKNF 428
            |...|:.      ::.|:.:|                  .:::|:           |.|....|.
Worm   623 MSNNYSFWNTVWYVLSTMLKGGCDFGPRAVSTRLLGGTWWVFYLV-----------IISAYTANL 676

  Fly   429 TVVLT------PIVQEVLDEIPSVQHMRFRLLEANSELDPLYFLEANHQLRQHVT----ASALDI 483
            ..|||      ||  :.||::.:...:.:..:...|.:.  :|.|:  ::..||.    ....|:
Worm   677 AAVLTVSRPYIPI--KNLDDLANQTTISYGTIRGGSTMQ--FFQES--RIAAHVKMWQYMKDKDV 735

  Fly   484 FIHFNRLSADKVHQR----------------------------GEQGSGAHFEIVPE--DIISMQ 518
            |:..|....::....                            |.:|.|.......|  |.||.|
Worm   736 FVTSNGKGVERALSMNYAYLMESTSLEYETQQNCNLTQIGGVLGSKGYGIALAKKSEWTDRISRQ 800

  Fly   519 LTMYLAKHSFLIDQLNEEIMWMRSVGLLSVWSRWELSESYLRNEQSFQVLGTMELYAIFLMVLVG 583
            :.:| ||.. :|:.  ::..|.||.|     :....:.|.:::::.  .|....:..:|:.:.||
Worm   801 ILLY-AKRG-IIEM--KKTKWWRSKG-----AACASTASAVKHDRF--ALSMYNVAGLFITLGVG 854

  Fly   584 LIVGLLVFILELV 596
            :::..:|.|.||:
Worm   855 IVLAAIVVIFELI 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	25/101 (25%)
glr-5	NP_505244.1	PBP1_iGluR_delta_like	26..418	CDD:107376
		ANF_receptor	38..377	CDD:279440
		PBP2_iGluR_Kainate	438..819	CDD:270432	79/411 (19%)
		Lig_chan	568..855	CDD:278489	56/326 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810