Protein Alignment Ir7e and Grin2a

DIOPT Version :9

• Sequence 1: NP_001138176.1
• Gene: Ir7e / 7354417
• FlyBaseID: FBgn0259189
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_032196.2
• Gene: Grin2a / 14811
• MGIID: 95820
• Length: 1464
• Species: Mus musculus
• Alignment Length: 769
• Identity: 120/769 - (15%)
• Similarity: 232/769 - (30%)
• Gaps: 301/769 - (39%)

  Fly    60 NKMMSTLFREWGLAPLQ----IVNVLRGVPWHP-------VPGRRHF------------------ 95
            :|..::.|.::|.:..|    ::.:::...||.       .||.|.|
Mouse   137 DKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYRDFISFIKTTVDNSFVGWDMQ 201

  Fly    96 NVIFTDSFAAFEEIRME-------------YYSREYNYNEHYFIFLQARD-------------RL 134
            |||..|:  :||:.:.:             |.|::    |...|..:||.             .|
Mouse   202 NVITLDT--SFEDAKTQVQLKKIHSSVILLYCSKD----EAVLILSEARSLGLTGYDFFWIVPSL 260

  Fly   135 LQGEMRLI---------------FDYCWRYRL--------IHCSIQVQKSNGDILFYSYYPFGEH 176
            :.|...||               :||....|:        ...|..::|       :||.|..:.
Mouse   261 VSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGLGILTTAASSMLEK-------FSYIPEAKA 318

  Fly   177 GC-----------------------------------------------SDMEPQLINRY-NGSM 193
            .|                                               .|.|.:.:.:: |.::
Mouse   319 SCYGQTEKPETPLHTLHQFMVNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENQTL 383

  Fly   194 LVEPDLFPRKLRNFFGCP-----LRCALWDVPPFLTLDE-DQEEVLRVNGGYEGRLLLALAEKMN 252
            .:...::|| .::|..|.     |.....:..||:.::: |......|......|..:.:....|
Mouse   384 SLRHAVWPR-YKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTN 447

  Fly   253 FTIAVRKVHVNMRDEALEMLRRD---EVDLTL---------------GGIRQTV-ARGMVATSSH 298
            ..:.|:|.......:.|:.|.|.   ..||.|               |.|.:.| .|.::|..|.
Mouse   448 EGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSL 512

  Fly   299 NYHQTREVFGVLASSYELSSFDILFY----------------------PYRLQIWMGILGVVALS 341
            ..::.|.         |:..|.:.|.                      |:...:|:.:..::.:.
Mouse   513 TINEERS---------EVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIV 568

  Fly   342 ALIQLIV---------GRMLRE---------RMGSRFWLNLELVFVGMPLLECPRSHTARLYCVM 388
            :.|.:.|         .|.|.:         .:|...||...|||.....::.|:..|:::...:
Mouse   569 SAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSV 633

  Fly   389 LMMYTLIIRTIYQGLLYHLIRTHQLNRWPQTIESLVQKNFTVVLTPIVQEVLDEIPSVQHMRFRL 453
            ...:.:|....|...|...:                          |.:|.:|::..:...:|:
Mouse   634 WAFFAVIFLASYTANLAAFM--------------------------IQEEFVDQVTGLSDKKFQ- 671

  Fly   454 LEANSELDPLYF-----------LEANH-QLRQHVT---------------ASALDIFIH----F 487
             ..:....|..|           :..|: .:.|::|               ...||.||:    .
Mouse   672 -RPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQRGVEDALVSLKTGKLDAFIYDAAVL 735

  Fly   488 N-RLSADKVHQRGEQGSGAHFEIVPEDIISMQLTMY-----LAKHSFLIDQLNEEI--MWMRSVG 544
            | :...|:..:....|||..|......|...:.:.:     ||...|:.|...||:  :|:..:
Mouse   736 NYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGI- 799

  Fly   545 LLSVWSRWELSESYLRNEQSFQVLGTM----ELYAIFLMVLVGLIVGLLVFILE 594
                          ..||:: :|:.:.    .:..:|.|:...:.:.|:.||.|
Mouse   800 --------------CHNEKN-EVMSSQLDIDNMAGVFYMLAAAMALSLITFIWE 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	21/114 (18%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..392	CDD:107373	38/267 (14%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	69/450 (15%)
		HisJ	<458..>541	CDD:223904	16/91 (18%)
		Lig_chan	556..828	CDD:278489	48/315 (15%)
		NMDAR2_C	839..1464	CDD:287527	120/769 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846471
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840