Protein Alignment Ir7e and Grik2

DIOPT Version :10

• Sequence 1: NP_001138176.1
• Gene: Ir7e / 7354417
• FlyBaseID: FBgn0259189
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: XP_011241422.1
• Gene: Grik2 / 14806
• MGIID: 95815
• Length: 943
• Species: Mus musculus
• Alignment Length: 766
• Identity: 133/766 - (17%)
• Similarity: 229/766 - (29%)
• Gaps: 275/766 - (35%)

  Fly    11 YDLSGEQMNHI-NEFVARAVLHVVHHYI--------LSVTPSLVLTLCCRSNHTCNFYNKMMSTL 66
            :|.|.|....| .:.:|..::...:|||        |.|.|.....:........|..|..:|::
Mouse   228 FDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSI 292

  Fly    67 FREWGLAPLQIVNVLRGVPWHPVPGRRHFNVIFTDSFAAFEEIRMEYYSREYNYNEHYFIFLQAR 131
            ..:|.:..||       .|..|..|       ..|.|...:...|      |:......:.:|..
Mouse   293 IEKWSMERLQ-------APPKPDSG-------LLDGFMTTDAALM------YDAVHVVSVAVQQF 337

  Fly   132 DRLLQGEMRLIFDYCWRYRLIHCSIQVQKSN-----GDILFYSYYPFGEHGCSDMEPQLINRYNG 191
            .::....::......||:.....|: :::::     |.|.|                   |:.||
Mouse   338 PQMTVSSLQCNRHKPWRFGTRFMSL-IKEAHWEGLTGRITF-------------------NKTNG 382

  Fly   192 SMLVEPDLFPRKLRNFFGCPL---------RCALWDVPPFLTLDEDQ------------------ 229
                        ||..|...:         :...||....|.:.|.|
Mouse   383 ------------LRTDFDLDVISLKEEGLEKIGTWDPSSGLNMTESQKGKPANITDSLSNRSLIV 435

  Fly   230 --------------EEVLRVNGGYEG---RLLLALAEKMNFTIAVRKVH---VNMRDEA------ 268
                          ::.|..|..:||   .||..|:..:.||..:|.|.   ...:|:.
Mouse   436 TTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNG 500

  Fly   269 -LEMLRRDEVDLTLGGIRQTVARGMVATSSHNYHQTREVFGVLASS--YELSS------FDILFY 324
             :..|...:.||.:..:..|..|..|...|       :.|..|..|  |...:      |..| .
Mouse   501 MVRELIDHKADLAVAPLAITYVREKVIDFS-------KPFMTLGISILYRKPNGTNPGVFSFL-N 557

  Fly   325 PYRLQIWMGILGVVALSALIQLIVGRMLRERMGSRF-WLNLELVFVGMPLLECPR-SHTARLYCV 387
            |....|||.||......:.:..::.|.      |:| |....         .|.. .|:.|..|.
Mouse   558 PLSPDIWMYILLAYLGVSCVLFVIARQ------SKFSWFKYP---------NCSHYHHSQRCLCT 607

  Fly   388 MLMMYTLIIRTIYQGLL----YHLIRTHQLNRWPQTIESLVQKNFTVV------LTPIVQEVLDE 442
            ..:       ..|..|.    |.....|..|  |.:  .:|:.|||::      :..::|:..:.
Mouse   608 QHL-------ESYMELCLFSPYEWYNPHPCN--PDS--DVVENNFTLLNSFWFGVGALMQQGSEL 661

  Fly   443 IPSVQHMR--------FRLLEANSELDPLYFLEANHQLRQHVTASALDIFIHFNRL-----SADK 494
            :|.....|        |.|:..:|                 .||: |..|:...|:     |||.
Mouse   662 MPKALSTRIVGGIWWFFTLIIISS-----------------YTAN-LAAFLTVERMESPIDSADD 708

  Fly   495 VHQR-----GEQGSGAHFEIVPEDIISMQLTMY----------LAK-------------HSFLID 531
            :.::     |....||......:..||....|:          |.|             ::||::
Mouse   709 LAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLME 773

  Fly   532 QLNEEIMWMRSVGLLSVWSRWE---------------------------------LSESYLR--- 560
            ....|.:..|:..|..:....:                                 :.|.:.|
Mouse   774 STTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG 838

  Fly   561 --NEQSFQ--VLGTMELYAIFLMVLVGLIVGLLVFILELV--SMRSIYLRK 605
              .|:|.:  .||...:..||:::..||::.:.|.:.|.:  |.::..|.|
Mouse   839 CPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEK 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	Periplasmic_Binding_Protein_Type_2	218..>313	CDD:473866	25/139 (18%)
Grik2	XP_011241422.1	PBP1_iGluR_Kainate	37..414	CDD:380605	40/237 (17%)
		Periplasmic_Binding_Protein_Type_2	430..835	CDD:473866	77/456 (17%)