DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7e and Grik2

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	XP_011241422.1	Gene:	Grik2 / 14806	MGIID:	95815	Length:	943	Species:	Mus musculus

Alignment Length:	766	Identity:	133/766 - (17%)
Similarity:	229/766 - (29%)	Gaps:	275/766 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YDLSGEQMNHI-NEFVARAVLHVVHHYI--------LSVTPSLVLTLCCRSNHTCNFYNKMMSTL 66
            :|.|.|....| .:.:|..::...:|||        |.|.|.....:........|..|..:|::
Mouse   228 FDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSI 292

  Fly    67 FREWGLAPLQIVNVLRGVPWHPVPGRRHFNVIFTDSFAAFEEIRMEYYSREYNYNEHYFIFLQAR 131
            ..:|.:..||       .|..|..|       ..|.|...:...|      |:......:.:|..
Mouse   293 IEKWSMERLQ-------APPKPDSG-------LLDGFMTTDAALM------YDAVHVVSVAVQQF 337

  Fly   132 DRLLQGEMRLIFDYCWRYRLIHCSIQVQKSN-----GDILFYSYYPFGEHGCSDMEPQLINRYNG 191
            .::....::......||:.....|: :::::     |.|.|                   |:.||
Mouse   338 PQMTVSSLQCNRHKPWRFGTRFMSL-IKEAHWEGLTGRITF-------------------NKTNG 382

  Fly   192 SMLVEPDLFPRKLRNFFGCPL---------RCALWDVPPFLTLDEDQ------------------ 229
                        ||..|...:         :...||....|.:.|.|
Mouse   383 ------------LRTDFDLDVISLKEEGLEKIGTWDPSSGLNMTESQKGKPANITDSLSNRSLIV 435

  Fly   230 --------------EEVLRVNGGYEG---RLLLALAEKMNFTIAVRKVH---VNMRDEA------ 268
                          ::.|..|..:||   .||..|:..:.||..:|.|.   ...:|:.
Mouse   436 TTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNG 500

  Fly   269 -LEMLRRDEVDLTLGGIRQTVARGMVATSSHNYHQTREVFGVLASS--YELSS------FDILFY 324
             :..|...:.||.:..:..|..|..|...|       :.|..|..|  |...:      |..| .
Mouse   501 MVRELIDHKADLAVAPLAITYVREKVIDFS-------KPFMTLGISILYRKPNGTNPGVFSFL-N 557

  Fly   325 PYRLQIWMGILGVVALSALIQLIVGRMLRERMGSRF-WLNLELVFVGMPLLECPR-SHTARLYCV 387
            |....|||.||......:.:..::.|.      |:| |....         .|.. .|:.|..|.
Mouse   558 PLSPDIWMYILLAYLGVSCVLFVIARQ------SKFSWFKYP---------NCSHYHHSQRCLCT 607

  Fly   388 MLMMYTLIIRTIYQGLL----YHLIRTHQLNRWPQTIESLVQKNFTVV------LTPIVQEVLDE 442
            ..:       ..|..|.    |.....|..|  |.:  .:|:.|||::      :..::|:..:.
Mouse   608 QHL-------ESYMELCLFSPYEWYNPHPCN--PDS--DVVENNFTLLNSFWFGVGALMQQGSEL 661

  Fly   443 IPSVQHMR--------FRLLEANSELDPLYFLEANHQLRQHVTASALDIFIHFNRL-----SADK 494
            :|.....|        |.|:..:|                 .||: |..|:...|:     |||.
Mouse   662 MPKALSTRIVGGIWWFFTLIIISS-----------------YTAN-LAAFLTVERMESPIDSADD 708

  Fly   495 VHQR-----GEQGSGAHFEIVPEDIISMQLTMY----------LAK-------------HSFLID 531
            :.::     |....||......:..||....|:          |.|             ::||::
Mouse   709 LAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLME 773

  Fly   532 QLNEEIMWMRSVGLLSVWSRWE---------------------------------LSESYLR--- 560
            ....|.:..|:..|..:....:                                 :.|.:.|
Mouse   774 STTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG 838

  Fly   561 --NEQSFQ--VLGTMELYAIFLMVLVGLIVGLLVFILELV--SMRSIYLRK 605
              .|:|.:  .||...:..||:::..||::.:.|.:.|.:  |.::..|.|
Mouse   839 CPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEK 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	25/139 (18%)
Grik2	XP_011241422.1	PBP1_iGluR_Kainate	37..414	CDD:380605	40/237 (17%)
Grik2	XP_011241422.1	Periplasmic_Binding_Protein_Type_2	430..835	CDD:389745	77/456 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846630
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840