DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7e and Grik1

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	XP_006522977.1	Gene:	Grik1 / 14805	MGIID:	95814	Length:	949	Species:	Mus musculus

Alignment Length:	483	Identity:	87/483 - (18%)
Similarity:	164/483 - (33%)	Gaps:	187/483 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 GSMLVEPDLFPRKLRNFFGCPLRCALWDVPPFL--TLDEDQEEVLRVNGGYEGRLLLAL------ 247
            |::|::|.|:.|.           ..|.:..||  .|.:...:|||:.|.:|     .:
Mouse     4 GTVLIQPGLWTRD-----------TSWTLLYFLCYILPQTSPQVLRIGGIFE-----TVENEPVN 52

  Fly   248 AEKMNFTIAVRKVH-----------------VNMRDEALEMLRRDEVDLTLG------------- 282
            .|::.|..||..::                 :|:.| :.|..||....|.||
Mouse    53 VEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFD-SFEASRRACDQLALGVAALFGPSHSSSV 116

  Fly   283 GIRQTVARGM----VATS-SHNYHQTREVFGV-LASSYELSS---FD-ILFYPYR--LQIWMGIL 335
            ...|::...:    :.|. .|.....|::|.: |...|...|   .| :|:|.::  ..::....
Mouse   117 SAVQSICNALEVPHIQTRWKHPSVDNRDLFYINLYPDYAAISRAVLDLVLYYNWKTVTVVYEDST 181

  Fly   336 GVVALSALI-------------QLIVGR-----MLRE-RMGSRFWLNLELVFVGMPLLECPRSHT 381
            |::.|..||             ||..|.     :|:| :.|..|::          :.:|.....
Mouse   182 GLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYV----------IFDCSHETA 236

  Fly   382 ARLYCVMLMM------YTLIIRTI-----------YQGL------LYHLIRTHQLNRWPQTIESL 423
            |.:...:|.|      |.....|:           |.|:      |.::...|        :.|:
Mouse   237 AEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPH--------VSSI 293

  Fly   424 VQK-NFTVVLTPIVQE--VLDEIPSVQHMRFRLLEANSELDPLYFLE-ANHQLRQHVTASALDIF 484
            ::| :...:..|...|  :||.:.:.        ||....|.:|.:. |:|:..| :|.|:|...
Mouse   294 IEKWSMERLQAPPRPETGLLDGVMTT--------EAALMYDAVYMVAIASHRASQ-LTVSSLQCH 349

  Fly   485 IH---------------------FNRLSADKVHQRGEQGSGAHFEIVPEDIISM------QLTMY 522
            .|                     ..|::.:|.     .|....|::   ||||:      :.:..
Mouse   350 RHKPWRLGPRFMNLIKEARWDGLTGRITFNKT-----DGLRKDFDL---DIISLKEEGTEKASGE 406

  Fly   523 LAKHSFLIDQLNEEIMWMRSVGLLSVWS 550
            ::||.:.:        |.:    :.:|:
Mouse   407 VSKHLYKV--------WKK----IGIWN 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	26/138 (19%)
Grik1	XP_006522977.1	PBP1_iGluR_Kainate	38..431	CDD:380605	76/438 (17%)
Grik1	XP_006522977.1	Periplasmic_Binding_Protein_Type_2	446..815	CDD:389745
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846565
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740