DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7e and Grid2

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_032193.1	Gene:	Grid2 / 14804	MGIID:	95813	Length:	1007	Species:	Mus musculus

Alignment Length:	792	Identity:	134/792 - (16%)
Similarity:	230/792 - (29%)	Gaps:	341/792 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NISALLNSYYD-LSGEQMNHINEFVARAVL------------HVVH--------HYIL------- 38
            ||:.::.:.:| :..|::|...:.:.||:|            .||.        |:|:
Mouse   203 NINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFISEVVETNLVAFDCHWIIINEEIND 267

  Fly    39 ---------SV-----------TPSLVLTLCCRSNH-----TCN-----FYNKMMSTLF------ 67
                     |:           .|..:...|.|.||     .|:     ..|..:|.|:
Mouse   268 VDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSSLCDPKDPFAQNMEISNLYIYDTVL 332

  Fly    68 ------------REW-GLAPLQIVNVLRGVPWHPVPGRRHFNVIFTDSFAAFEEIR--------- 110
                        |:| .:|.|..:. ....||.   |.|          :..|.|:
Mouse   333 LLANAFHKKLEDRKWHSMASLSCIR-KNSKPWQ---GGR----------SMLETIKKGGVNGLTG 383

  Fly   111 -MEYYSREYNYNEHYFIF-LQARDRLLQGEMRLIFDYCWRYRLIHCSIQVQKSNGDILFYSYYPF 173
             :|:.....|.|.|:.|. ....:.|.:|..:|   .||.        .|...||.:
Mouse   384 DLEFGENGGNPNVHFEILGTNYGEELGRGVRKL---GCWN--------PVTGLNGSL-------- 429

  Fly   174 GEHGCSDMEPQLINRYNG------SMLVEPDLF--------PRKLRNF----------------- 207
                   .:.:|.|...|      ::|.||.:.        |:|.:.|
Mouse   430 -------TDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYE 487

  Fly   208 --------FGCPLRCALW------------DVP-PFLTLDEDQEEVLRVNGGYEGRLLLALAEKM 251
                    :|.|.....|            |:. ..||:..|:|.|:.....|           |
Mouse   488 IYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRY-----------M 541

  Fly   252 NFTIAVRKVHVNMRDEALEMLRRDEVDLTLGGIRQTVARGMVATSSHNYHQTREVFGVLASSYEL 316
            ::::.|             :|||.|                         :|.::|..||
Mouse   542 DYSVGV-------------LLRRAE-------------------------KTVDMFACLA----- 563

  Fly   317 SSFDILFYPYRLQIWMGILGVVALSALIQLIVGRMLRERMGSRFWLNLELVFVGMPLLECPRSHT 381
                    |:.|.:|..|.|.|.|..|:..::.           |||       .|.|:.....:
Mouse   564 --------PFDLSLWACIAGTVLLVGLLVYLLN-----------WLN-------PPRLQMGSMTS 602

  Fly   382 ARLYCVMLMMYTLIIRTIYQG--LLYHLIRTH-QLNRW---PQTIESLVQKNFTVVLT-----PI 435
            ..||..|..:|...::   ||  :.|..:.|. .:..|   ...:.|....|....||     ..
Mouse   603 TTLYNSMWFVYGSFVQ---QGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESS 664

  Fly   436 VQEVLD-----EIP--------SVQHMRFRLLEANSELDPLY-----FLEANHQLRQHVTASALD 482
            :|.:.|     :||        ..||:|.:.|.. .|.|.:|     .:..::....:|..|...
Mouse   665 IQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNP-FERDSMYSQMWRMINRSNGSENNVLESQAG 728

  Fly   483 I----------------------------FIHFNRLSADKVHQRGEQGSGAHFEIVPEDIISMQL 519
            |                            |.......||:.:....|....:.::..:.|:.:|.
Mouse   729 IQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQ 793

  Fly   520 T--MYLAKHSFLIDQLNEEIMWMRSVGLLSVWSRWELSESYLRNEQSFQVLGTMELYAIFLMVLV 582
            :  |.:.||.           |....|...::|..:.       :|....|....|..:|.::..
Mouse   794 SGDMDILKHK-----------WWPKNGQCDLYSSVDA-------KQKGGALDIKSLAGVFCILAA 840

  Fly   583 GLIVGLLVFILE 594
            |:::..|:.:||
Mouse   841 GIVLSCLIAVLE 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	17/95 (18%)
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		22/141 (16%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:385651	45/250 (18%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	77/460 (17%)
		Interaction with AP4M1. /evidence=ECO:0000250\|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846506
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740