DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7e and Gria4

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	XP_006509904.1	Gene:	Gria4 / 14802	MGIID:	95811	Length:	912	Species:	Mus musculus

Alignment Length:	510	Identity:	94/510 - (18%)
Similarity:	155/510 - (30%)	Gaps:	197/510 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 SNHTCNFYNKMMSTLFREWGLAPLQIVNVLRG----------VPWHPVPGRRHFNVIFTDSFAAF 106
            :|..|:.|::.:..:|   ||...:.|:.|..          .|..|..|...|.:....|....
Mouse    80 TNAFCSQYSRGVFAIF---GLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRGA 141

  Fly   107 EEIRMEYYSREYNYNEHYFIFLQARDR---LLQGEMRLIFDYCWR-------------YR----- 150
            ....:::|  |:|    .|:||...||   :||..|.......|.             ||
Mouse   142 LLSLLDHY--EWN----CFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEE 200

  Fly   151 ---------LIHCSIQ-VQKSNGDILFYSYYPFGEH------GCSDMEPQLINRY-------NGS 192
                     :|.|.|: :|.....|:....:..|.|      |..|:.   :.|:       .|.
Mouse   201 LDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDIS---LERFIHGGANVTGF 262

  Fly   193 MLVEPDLFPRKLRNFFGCPLRCALWD--------------VPPFLTLDEDQEEVLRVNGGYEGRL 243
            .||:           |..|:...|.|              .||..|      ..|.    |:|.|
Mouse   263 QLVD-----------FNTPMVTKLMDRWKKLDQREYPGSETPPKYT------SALT----YDGVL 306

  Fly   244 LLALAEKMNFTIAVRKVHVNMRDEALEMLRRDEVDLTLGG----------------------IRQ 286
            ::|                    |....|||.::|::..|                      ::|
Mouse   307 VMA--------------------ETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQ 351

  Fly   287 TVARGMVATSSHNYH-----QTREVFGVLASSYELSSFDILFYPYRLQIWMGILGVVAL------ 340
            ...:|:......:::     .|.:||       ||.|..    |.::..|..:..:|.:
Mouse   352 VRIQGLTGNVQFDHYGRRVNYTMDVF-------ELKSTG----PRKVGYWNDMDKLVLIQDAPTL 405

  Fly   341 ---SALIQ--LIVGRMLRERMGSRFWLNLELVFVGMPLLECPRSHTARLYCVMLMMYTLIIRTIY 400
               :|.|:  .:|...:.|.....:..|.|: |.|....|.        |||.|.  :.|.:.|
Mouse   406 GNDTAAIENRTVVVTTIMESPYVMYKKNHEM-FEGNDKYEG--------YCVDLA--SEIAKHI- 458

  Fly   401 QGLLYHL---------IRTHQLNRWPQTIESLVQKNFTVVLTPIV-----QEVLD 441
             |:.|.:         .|......|...:..||.....:.:.|:.     :||:|
Mouse   459 -GIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVID 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	20/135 (15%)
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	69/383 (18%)
Gria4	XP_006509904.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	23/112 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846602
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740