DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir7e and GRIN3A

DIOPT Version :9

Sequence 1:NP_001138176.1 Gene:Ir7e / 7354417 FlyBaseID:FBgn0259189 Length:608 Species:Drosophila melanogaster
Sequence 2:NP_597702.2 Gene:GRIN3A / 116443 HGNCID:16767 Length:1115 Species:Homo sapiens


Alignment Length:772 Identity:142/772 - (18%)
Similarity:252/772 - (32%) Gaps:272/772 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MNISALLNSYYDLSGEQMNHINEFVARAVLHVVHHYILSVTPSLVLTLCCRSNHTCNFYNKMMST 65
            :||:|.|.|..||             .:.|.:....|.:.||::|:..|...:....|   .::|
Human   295 INITANLPSTQDL-------------LSFLQIQLESIKNSTPTVVMFGCDMESIRRIF---EITT 343

  Fly    66 LF------REWGLAPLQIVNVLR--GVPWHPVP-GRRHFNVIFTDSFAAFEEIRMEYYSREYNYN 121
            .|      ..|.|...|.|..||  |:|...:. |:...:|     |..:.:..||..:|..   
Human   344 QFGVMPPELRWVLGDSQNVEELRTEGLPLGLIAHGKTTQSV-----FEHYVQDAMELVARAV--- 400

  Fly   122 EHYFIFLQARDRLLQGEMRLI----------------FDYCWR------YRLIHCSIQVQ----- 159
                    |...::|.|:.||                ..|..|      :|.:..||:|:     
Human   401 --------ATATMIQPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIV 457

  Fly   160 --KSNGDILFYSYYPFGEHGCSDMEPQLINRYNGSMLVEPDLFP---RKLRNFFGCP----LRCA 215
              ::|..|....:.|.|:    .|..:|.:...|.::::..::|   ::.:..|..|    ||..
Human   458 SSENNFFIWNLQHDPMGK----PMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVV 518

  Fly   216 LWDVPPFLTLDEDQEEVLRVNG-------------------------------------GYEGRL 243
            .....||:...|..:|.|...|                                     ||...|
Human   519 TLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDL 583

  Fly   244 LLALAEKMNFTI-----------AVRKVHVN--MRDEALEMLRRDEVDLTLGGIRQTVARGMVAT 295
            |..:||.|||..           |.:..|..  :.|     |.|....:.:.......||..|..
Human   584 LEKIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGD-----LLRGTAHMAVTSFSINTARSQVID 643

  Fly   296 SSHNYHQTREVFGVLASSYELSS-FDILFYPYRLQIWMGILGVV--------------------- 338
            .:..:..|.  .|:|..:.:.:: .....:|....:|:||...:                     
Human   644 FTSPFFSTS--LGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGLTPK 706

  Fly   339 ------------ALSALIQLIVGRMLRER----MGSRFWLNLELVFVGMPLLECPRSHTARLYCV 387
                        ||:....|:.||.:..:    ...||.:||..:|    .:.|..::||.|..|
Human   707 GRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIF----CMFCLSTYTANLAAV 767

  Fly   388 MLMMYTLIIRTIY---------------QGLLYHLIRTHQLNRWPQTIESLVQKNFTVVLTPIVQ 437
            |      :...||               ||..:..:|       ..:.|..|:::|         
Human   768 M------VGEKIYEELSGIHDPKLHHPSQGFRFGTVR-------ESSAEDYVRQSF--------- 810

  Fly   438 EVLDEIPSVQHMRFRLLEANSELDPLYFLEANHQLRQHVTASALDIFIHFNRL-------SAD-K 494
                  |.: |...|.....:..|.:.:|:.:.:        .||.||....|       .|| |
Human   811 ------PEM-HEYMRRYNVPATPDGVEYLKNDPE--------KLDAFIMDKALLDYEVSIDADCK 860

  Fly   495 VHQRGE----QGSGAHFEIVPEDIISMQLTMYLAK---HSFLIDQLNEEIMWMRSVGLLSVWSRW 552
            :...|:    :|.|  ..:.|...::..::..:::   |.|: |.|:::  |.|.|..       
Human   861 LLTVGKPFAIEGYG--IGLPPNSPLTANISELISQYKSHGFM-DMLHDK--WYRVVPC------- 913

  Fly   553 ELSESYLRNEQSFQVLGTMEL-----YAIFLMVLVGLIVGLLVFILELVSMRSIYLR 604
                    .::||.|..|:::     ..:|:::.:|..:.:|..|.|.:..|.:..|
Human   914 --------GKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPR 962

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir7eNP_001138176.1 PBPb 218..>313 CDD:214497 26/144 (18%)
GRIN3ANP_597702.2 PBP1_iGluR_NMDA_NR3 30..497 CDD:107372 48/237 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 59..118
ANF_receptor 127..469 CDD:279440 43/205 (21%)
PBP2_iGluR_NMDA_Nr3 512..908 CDD:270438 77/448 (17%)
Lig_chan 676..942 CDD:278489 56/326 (17%)
PPP2CB binding site. /evidence=ECO:0000250 951..987 3/12 (25%)
GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7 1062..1095
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156094
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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