Protein Alignment Ir7e and gria4

DIOPT Version :10

• Sequence 1: NP_001138176.1
• Gene: Ir7e / 7354417
• FlyBaseID: FBgn0259189
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: XP_031751480.1
• Gene: gria4 / 100125052
• XenbaseID: XB-GENE-5838893
• Length: 902
• Species: Xenopus tropicalis
• Alignment Length: 676
• Identity: 126/676 - (18%)
• Similarity: 219/676 - (32%)
• Gaps: 255/676 - (37%)

  Fly    22 NEFVARAVLHVVHHY-ILSVTPSLVLTLCCRSNHTCNFYNKMMSTLFREWGLAPLQIVNVLRG-- 83
            ||  :.|:.::|.|. .:..:.|..:|     |..|:.|::.:..:|   ||...:.|:.|..
 Frog    56 NE--SEALFNLVPHVDNIETSNSFAVT-----NAFCSQYSRGVFAIF---GLYDKRSVHTLTSFC 110

  Fly    84 --------VPWHPVPGRRHFNVIFTDSFAAFEEIRMEYYSREYNYNEHYFIFLQARDR---LLQG 137
                    .|..|..|...|.:....|      :|....|...:|..::::||...||   :||.
 Frog   111 SALHISLITPSFPTEGESQFVLQLRPS------LRGALLSLLDHYGWNHYVFLYDTDRGYSILQA 169

  Fly   138 EMRLIFDYCWR-------------YR--------------LIHCSIQ-VQKSNGDILFYSYYPFG 174
            .|.......|:             ||              :|.|.:: :|.....|:....:..|
 Frog   170 IMEKAGQNGWQVSAICVENFNDASYRRLLEDLDRRQENKFVIDCEVERLQNILEQIVSVGKHVKG 234

  Fly   175 EH------GCSDMEPQLINRY-------NGSMLVEPDLFPRKLRNFFGCPLRCAL---WDVPPFL 223
            .|      |..|:.   ::|:       .|..||:           |..|:...|   |.
 Frog   235 YHYIIANLGFKDIS---LDRFMHGGANVTGFQLVD-----------FNTPIVTELMQRWK----- 280

  Fly   224 TLDEDQEEVLRVNGGYEGRLLLALAEKMNFTIAVRKVHVNMRDEALEMLRRDEVDLTLGGIRQTV 288
            |||:.:         |.|.     .....:|.|:....|.:..||..:|||.::||:    |:..
 Frog   281 TLDQRE---------YPGS-----ESPPKYTSALTYDGVLVMAEAFRILRRQKIDLS----RRGN 327

  Fly   289 ARGMVATSSHNYHQTREVFGVLASSYELSSFDILFYPYRLQIWMGILGVVALSALIQLIVGRMLR 353
            |...:|..:..:.|..::...|.                             ...||.:.|.:..
 Frog   328 AGDCLANPAAPWGQGIDMERTLK-----------------------------QVRIQGLTGNIQF 363

  Fly   354 ERMGSRFWLNLELVFVGMPLLECPRSHTAR-------LYCVMLMMYTLIIRTIYQGLLYHLIRTH 411
            :..|.|       |...|.:||. :|:..|       :..::|:.:....:....|:
 Frog   364 DHYGRR-------VNYTMDVLEL-KSNGLRKIGYWNDMDKLVLLQHEPAFKNDSSGI-------- 412

  Fly   412 QLNRWPQTIESLVQKNFTVVLTPIVQEVLDEIPSVQHMR-FRLLEANSELDPLYFLEANHQLRQH 475
                          :|.||::|.|:     |.|.|.:.: ..|||.|.:.:. |.::..:::.:|
 Frog   413 --------------ENRTVIVTTIL-----EAPYVMYKKNHELLEGNDKFEG-YCVDLAYEIAKH 457

  Fly   476 VTASALDIFIHFNRLSADKVHQRGEQGSGAHFEIVPEDIISMQLTMYLAKHSFLIDQLNEEIMWM 540
            :                         |......|||:.       .|.|:.|       |..:|.
 Frog   458 I-------------------------GIKYKIAIVPDG-------KYGARDS-------ETKIWN 483

  Fly   541 RSVGLLSVWSRWELS----------ESYLRNEQSFQVLGTMEL-------------------YAI 576
            ..||.| |:.:.|::          |..:...:.|..||...:                   |.|
 Frog   484 GMVGEL-VYGKAEIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEI 547

  Fly   577 FLMVLVGLIVGLLVFILELVSMRSIY 602
            : |.:|...:|:.| :|.|||..|.|
 Frog   548 W-MCIVFAYIGVSV-VLFLVSRFSPY 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	Periplasmic_Binding_Protein_Type_2	218..>313	CDD:473866	20/94 (21%)
gria4	XP_031751480.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	81/433 (19%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	44/206 (21%)