DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7d and grin3a

DIOPT Version :9

Sequence 1:	NP_001138175.1	Gene:	Ir7d / 7354416	FlyBaseID:	FBgn0259190	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	XP_009303361.1	Gene:	grin3a / 564832	ZFINID:	ZDB-GENE-130530-780	Length:	1111	Species:	Danio rerio

Alignment Length:	482	Identity:	97/482 - (20%)
Similarity:	156/482 - (32%)	Gaps:	136/482 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 VFPRRLKNLHGCPLSVIVWDIPPYMRINWKSSDPMDGLDGLDGL---------------LLRIVA 248
            ||.|.:.:...||...:..|  |.............||.|.:..               ||..:|
Zfish   532 VFTRDVDDEGLCPAGQLCLD--PLTNDTALLESLFQGLQGANDTVPLEFKKCCYGYCIDLLEKLA 594

  Fly   249 RKMNFTLKLIPNEPNGLIGG---SSFMNGTFTGAYKMLRERRANITIGCAACTPERSTFLEATSP 310
            ..|.|...|.      ::|.   .::.||.:||....|....|::.:...:....||..::.|||
Zfish   595 EDMGFDFDLY------IVGDGKYGAYKNGRWTGLVGDLMSGAAHLAVTSFSINSARSQVIDFTSP 653

  Fly   311 YSQMSYIIVLQARGGYSIYEVMLFPFEKYTWLLLSTILGLH----WIVGSRWRMP---SP----- 363
            :...|..|:::.|...:.....::|.....|  |...:.||    ::....|:.|   :|
Zfish   654 FFSTSLGILVRTRDTAAPIGAFMWPLHWSMW--LGIFVSLHVTAVFLTLYEWKSPFGMTPRGRNR 716

  Fly   364 ---------------ILAG-------------------WMLWIFVIRASYEASVFNFIQNSPVKP 394
                           ||.|                   |.::.....::|.|::      :.|..
Zfish   717 DRVFSFSSALNVCYAILFGRTAAIKPPKCWTGRFLMNLWAIFCLFCLSTYTANL------AAVMV 775

  Fly   395 SPRTLDQALSG-----------GFRFITDHASYRMTLKIPSF----QGKTLISAGQPVDVFDALL 444
            ..:|.:| |||           ||||.|...|........||    :.....:|....|..|.|.
Zfish   776 GEKTYEQ-LSGIHDPKLHHPSQGFRFGTVRESSAEDYVKKSFPEMHEYMRRYNAPTTPDGIDHLK 839

  Fly   445 KAPWKTGAFTSRAFLADHLVRHRKHRNQLVILAEKIVDNMLCMYFPHG----SYFAWEINKLLFN 505
            ..|.|..||.....|.|:...           |:|...::|...:..|    |.....|::|:..
Zfish   840 DDPQKLDAFIMDKALLDYWAH-----------ADKXYISLLLTGYGIGLKQNSPLTSNISELVSQ 893

  Fly   506 MRSFGIFQH-HSQILAWDNLPTTTDTDTP-GKRIHSSTESVATGFAE-SMSFVVAALNCLMGALC 567
            .:|.|.... |.:   |..:       .| |||..:.||::..|... |..||:         ||
Zfish   894 YKSDGFMDMLHDK---WYKV-------VPCGKRSFAVTETLQMGIKHFSGLFVM---------LC 939

  Fly   568 ISIVVFGLELLSRRRHWTGLEWLFERV 594
            :.:   .|.||:.........|:..|:
Zfish   940 VGV---ALSLLTTLGEHIVHRWVIPRM 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7d	NP_001138175.1	None
grin3a	XP_009303361.1	Periplasmic_Binding_Protein_Type_1	36..502	CDD:299141
		ANF_receptor	132..452	CDD:279440
		PBP2_iGluR_NMDA_Nr3	518..908	CDD:270438	79/406 (19%)
		Lig_chan	682..941	CDD:278489	60/297 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810