DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7d and Grik2

DIOPT Version :9

Sequence 1:	NP_001138175.1	Gene:	Ir7d / 7354416	FlyBaseID:	FBgn0259190	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_062182.1	Gene:	Grik2 / 54257	RGDID:	2733	Length:	908	Species:	Rattus norvegicus

Alignment Length:	241	Identity:	55/241 - (22%)
Similarity:	94/241 - (39%)	Gaps:	65/241 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 SVIVWDI--PPYMRINWKSSDPMDGLDGLDGL---LLRIVARKMNFT--LKLIPNEPNGLIGGSS 270
            |:||..|  .||:... ||..|:.|.|..:|.   |||.::..:.||  ::|:   .:|..|...
  Rat   432 SLIVTTILEEPYVLFK-KSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLV---EDGKYGAQD 492

  Fly   271 FMNGTFTGAYKMLRERRANITIGCAACTPERSTFLEATSPYSQMS-------------------- 315
            .:||.:.|..:.|.:.:|::.:...|.|..|...::.:.|:..:.
  Rat   493 DVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLN 557

  Fly   316 ------YIIVLQARGGYSIYEVMLFPFEKYTWLLLS-------------TILGLHWI-VGSRWR- 359
                  ::.||.|..|.|....::..|..|.|....             |:|...|. ||:..|
  Rat   558 PLSPDIWMYVLLACLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMRQ 622

  Fly   360 ----MPSPI---LAGWMLWIF--VIRASYEASVFNFI----QNSPV 392
                ||..:   :.|.:.|.|  :|.:||.|::..|:    ..||:
  Rat   623 GSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPI 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7d	NP_001138175.1	None
Grik2	NP_062182.1	Periplasmic_Binding_Protein_Type_1	34..414	CDD:299141
		ANF_receptor	52..395	CDD:279440
		Periplasmic_Binding_Protein_Type_2	430..800	CDD:304360	55/241 (23%)
		Glutamate binding. /evidence=ECO:0000269\|PubMed:15721240, ECO:0000269\|PubMed:17115050, ECO:0007744\|PDB:1S50, ECO:0007744\|PDB:1S7Y, ECO:0007744\|PDB:2I0B, ECO:0007744\|PDB:2I0C	516..518		0/1 (0%)
		Lig_chan	562..831	CDD:278489	26/107 (24%)
		Glutamate binding. /evidence=ECO:0000269\|PubMed:15721240, ECO:0000269\|PubMed:17115050, ECO:0007744\|PDB:1S50, ECO:0007744\|PDB:1S7Y, ECO:0007744\|PDB:2I0B, ECO:0007744\|PDB:2I0C	689..690
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900