DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7d and GluRIIB

DIOPT Version :9

Sequence 1:	NP_001138175.1	Gene:	Ir7d / 7354416	FlyBaseID:	FBgn0259190	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	104/548 - (18%)
Similarity:	186/548 - (33%)	Gaps:	138/548 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LLEEQLASQISATLQKIFINGLAVYNFGV--FISTSYEEMDRDRVILVHQVLNRNLYPPNFPV-- 86
            ::...:...::.:...:|:..|..:..|:  |.|       ||..:.|..|..|...||  ||
  Fly   224 VINASIGYNMTGSFNHLFLTNLDTHLSGIDGFYS-------RDFTVAVAAVRIRTYVPP--PVHD 279

  Fly    87 -AVVLASKMNRKITA----QVFTQLLFVQNAEQAIAIAEGVNRNGLCVIVL------------LT 134
             ..|..:.::.:.::    .|:..::...|     |:.|...|.|..:...            |.
  Fly   280 EIDVFDNSVDTRFSSLGSQLVYDSIVLFYN-----ALLEISQRPGFYIPNFSCGRGFWQPGPRLV 339

  Fly   135 SQPER--PIMTKIFTYFMQERYNINVVILVPRLHGV-QAFNVRPYTP-----TSCSSLEPVEID- 190
            .|.::  |.|.|  ..|..:|..||.       .|. :.||:..|.|     |...:.|...:|
  Fly   340 EQMKQITPKMVK--PPFKTQRLQINA-------DGQREDFNLEVYNPIIDRVTHIWNKEFQLVDF 395

  Fly   191 --IKDGDLWDVFPRRLKNLHGCPLSVIVWDI-----PPYMRINWKSSDP----MDGLDGLDGL-- 242
              :::.....:..:||:|........|.:.:     .||  .:|: .:|    .:|.:..:|.
  Fly   396 EKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPY--FSWR-EEPEGVHYEGNERFEGYAV 457

  Fly   243 -LLRIVARKMNFTLKLIPNEPNGLIGGSSFMNGTFTGAYKMLRERRANITIGCAACTPERSTFLE 306
             |:.::|::..|.....|...| ..|........:.|..:.|.:..|.|.|.....|..|.:.::
  Fly   458 DLIYMLAQECKFDFNFEPVRDN-KYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVD 521

  Fly   307 ATSPYSQMSYIIVLQARGGY-------SIYEVMLFPFEKYTWLLLSTILGLHWIVGSRWRMPSPI 364
            .|.|:.|:...|:     .|       .|| ..|.|:....||.                    :
  Fly   522 FTVPFMQLGISIL-----SYKEPPPKADIY-AFLNPYNAEVWLF--------------------V 560

  Fly   365 LAGWMLWIFVIRASYEASVFNFIQNSPVKPSPRTLDQALSGGFRFITDHASYRMTLKIPSF--QG 427
            :...|:..|.:  .:...:..:..:.||:...|.::       |....|.|..:.|.:.|.  ||
  Fly   561 MIAMMITAFAL--IFTGRIDQYEWDQPVENVNREME-------RQNIWHLSNALWLVLGSMLNQG 616

  Fly   428 KTLISAGQPVDVFDALLKAPW-------------KTGAFTSRAFLADHLVRHRKHRNQLVILAEK 479
            ..|:..|.|:    .||.|.|             |..||.:.:.:|..:.......:|..:....
  Fly   617 CDLLPRGLPM----RLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGT 677

  Fly   480 IVDNMLCMYFPHG----SYFAWEINKLL 503
            |......:||...    :..||  ||:|
  Fly   678 IRGGATSVYFSESNDTDNRMAW--NKML 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7d	NP_001138175.1	None
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	37/191 (19%)
		ANF_receptor	41..378	CDD:279440	34/176 (19%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	63/327 (19%)
		Lig_chan	555..822	CDD:278489	34/184 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462666
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740