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Protein Alignment Ir7d and GRIN2D

DIOPT Version :9

Sequence 1:	NP_001138175.1	Gene:	Ir7d / 7354416	FlyBaseID:	FBgn0259190	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_000827.2	Gene:	GRIN2D / 2906	HGNCID:	4588	Length:	1336	Species:	Homo sapiens

Alignment Length:	435	Identity:	77/435 - (17%)
Similarity:	140/435 - (32%)	Gaps:	183/435 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 IPPYMRINWKSSDPMDG------------LDGLDGLLLRIVARKMNFT--LKLIPNEPNGLIGGS 269
            :|...::|...|.|.|.            :|     :|:.:|..:.|:  |.|:.|..:|
Human   460 VPCRSQLNRTHSPPPDAPRPEKRCCKGFCID-----ILKRLAHTIGFSYDLYLVTNGKHG----- 514

  Fly   270 SFMNGTFTGAYKMLRERRANITIGCAACTPERSTFLEATSPYSQMSYIIVLQARGGYSIYEVMLF 334
            ..::|.:.|....:..:||::.||......|||..::.:.|:.:....:::....|.......|.
Human   515 KKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLE 579

  Fly   335 PFEKYTWLLL----STILGLHWIV--------------------GSRWRMPSPILAGWMLWIFVI 375
            |:....|:::    .|::.:...:                    ||.:.:...|   |:||..|.
Human   580 PYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSI---WLLWALVF 641

  Fly   376 R----------------------------ASYEASVFNFI----------------------QNS 390
            .                            |||.|::..|:                      |..
Human   642 NNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYP 706

  Fly   391 PVK----PS-----------------------PR---TLDQALSGGF-RFITDHA--SYRMTLK- 421
            |:|    |:                       ||   .|.|..:|.. .||.|.|  :| |..|
Human   707 PLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNY-MARKD 770

  Fly   422 -----IPSFQGKTLISAG------------QPVDVFDALLKAPWKTGAFTSRAFLADHLVRHRK- 468
                 :....||...:.|            :|:|:  |||:            ||.|..:...:
Human   771 EGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDL--ALLQ------------FLGDDEIEMLER 821

  Fly   469 -------HRNQLVILAEKI-VDNMLCMYF----PHG---SYFAWE 498
                   |.:::.:::.|: :|||..:::    ..|   ..||||
Human   822 LWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWE 866

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.