DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7d and GRIK1

DIOPT Version :9

Sequence 1:	NP_001138175.1	Gene:	Ir7d / 7354416	FlyBaseID:	FBgn0259190	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_001317923.1	Gene:	GRIK1 / 2897	HGNCID:	4579	Length:	949	Species:	Homo sapiens

Alignment Length:	231	Identity:	49/231 - (21%)
Similarity:	85/231 - (36%)	Gaps:	64/231 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 PYMRINWKSSDPMDGLDGLDGLLLRIVARKMN-----FTLKLIPNEPNGLIGGSSFMNGTFTGAY 280
            ||:... ||..|:.|.|..:|..|.::....|     :.:||:   |:|..|..: ..|.:.|..
Human   458 PYVMYR-KSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLV---PDGKYGAQN-DKGEWNGMV 517

  Fly   281 KMLRERRANITIGCAACTPERSTFLEATSPYSQMS--------------------------YIIV 319
            |.|.:.||::.:.....|..|...::.:.|:..:.                          ::.|
Human   518 KELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYV 582

  Fly   320 LQARGGYSIYEVMLFPFEKYTWLLLS-------------TILGLHWI-VGSRWR-----MPSPI- 364
            |.|..|.|....::..|..|.|....             |:|...|. ||:..:     ||..:
Human   583 LLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALS 647

  Fly   365 --LAGWMLWIF--VIRASYEASVFNFI----QNSPV 392
              :.|.:.|.|  :|.:||.|::..|:    ..||:
Human   648 TRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPI 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7d	NP_001138175.1	None
GRIK1	NP_001317923.1	Periplasmic_Binding_Protein_Type_1	35..430	CDD:324556
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:328725	49/231 (21%)
		Glutamate binding. /evidence=ECO:0000250	531..533		0/1 (0%)
		Glutamate binding. /evidence=ECO:0000250	704..705
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900