Protein Alignment Ir7d and GRID1

DIOPT Version :9

• Sequence 1: NP_001138175.1
• Gene: Ir7d / 7354416
• FlyBaseID: FBgn0259190
• Length: 594
• Species: Drosophila melanogaster
• Sequence 2: NP_060021.1
• Gene: GRID1 / 2894
• HGNCID: 4575
• Length: 1009
• Species: Homo sapiens
• Alignment Length: 759
• Identity: 143/759 - (18%)
• Similarity: 250/759 - (32%)
• Gaps: 275/759 - (36%)

  Fly    24 QHLLEEQLASQISATLQKIFINGLAVYNFGVFISTSYEEMDRDRVILVHQVLNRNLYPP------ 82
            |..|::.....:..:|||:..|...|:. .:|.:...||::|.|..|...:|   |..|
Human   179 QSFLDQASRLGLDVSLQKVDKNISHVFT-SLFTTMKTEELNRYRDTLRRAIL---LLSPQGAHSF 239

  Fly    83 -NFPVAVVLASK------MNRKITAQVFTQLLFVQNAEQAIAIAEGV----------NRNGLCVI 130
             |..|...||||      :|.:|:......|  |.:|...:.:...:          .||...:.
Human   240 INEAVETNLASKDSHWVFVNEEISDPEILDL--VHSALGRMTVVRQIFPSAKDNQKCTRNNHRIS 302

  Fly   131 VLLTSQPERPI-MTKIFTYFMQERYNINVVILVPRLH---------------------------- 166
            .||....|..: |.:|...::.:    :|::|....|
Human   303 SLLCDPQEGYLQMLQISNLYLYD----SVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGR 363

  Fly   167 ---------------GVQAF---NVRPYTPTSCSSLEPVEIDIKDGDLWDVFPRRLKNLHGCPLS 213
                           ||..|   :..||          |:.:|......:.|.:.::.|
Human   364 SMLDTIKKGHITGLTGVMEFREDSSNPY----------VQFEILGTTYSETFGKDMRKL------ 412

  Fly   214 VIVWDIPPYMRINWKSSDPMDGLDG----------LDGLLLRIVA------------------RK 250
                       ..|   |...||:|          |.||.|::|.                  |.
Human   413 -----------ATW---DSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRY 463

  Fly   251 MNFTLKL-------------IPNEPNGLIGGSSFMNGTFTGAYKMLRERRANITIGCAACTPERS 302
            ..|::.:             |...|:|.. |....|.::.|....|..:||::.|.....||||.
Human   464 KGFSIDVLDALAKALGFKYEIYQAPDGRY-GHQLHNTSWNGMIGELISKRADLAISAITITPERE 527

  Fly   303 TFLEATSPYSQMSY-IIVLQARGGYSIYEVMLFPFEKYTWLLLST---ILG-------------- 349
            :.::.:..|...|. |::.:.....||:. :..||:...|..::.   ::|
Human   528 SVVDFSKRYMDYSVGILIKKPEEKISIFS-LFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRA 591

  Fly   350 -------------LH---WIV-------GSRWRMPSP----ILAGWMLWIFVIRASYEASVFNFI 387
                         ||   |||       |....:.|.    ::..|.|:..::.:||.|::..|:
Human   592 QSAAQPRPSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFL 656

  Fly   388 QNSPVKPSPRT---LDQALSGGFRFITDHASYRMTLKIPSFQGKTLISAGQPVDVFDALLKAPWK 449
            ..|.:....||   |.:.:...:..:.|.|.|..      |:.|    ...|::. |:.....|:
Human   657 TVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEY------FRAK----GTNPLEQ-DSTFAELWR 710

  Fly   450 TGAFTSRAFLADHLVRHRKHRNQLVILAEKIVDNMLCMYFPHGSY-FAWEINKLLF--------- 504
            |   .|:...||:.|   ...::.:..|:|            |:| |.|::..:.:
Human   711 T---ISKNGGADNCV---SSPSEGIRKAKK------------GNYAFLWDVAVVEYAALTDDDCS 757

  Fly   505 --------NMRSFGI-FQHHS--------QILAWDNLPTTTDTDTPGKR---------IHSSTES 543
                    :.:.:|| .||.|        :||   .|..|.|.|...::         :.|...:
Human   758 VTVIGNSISSKGYGIALQHGSPYRDLFSQRIL---ELQDTGDLDVLKQKWWPHMGRCDLTSHASA 819

  Fly   544 VATGFAESM-SFVVAALNCLMG-ALCISIVVFGLELL--SRRRH 583
            .|.|.:..: ||  |.:.|::. .|.::.:|..|||.  |.|.|
Human   820 QADGKSLKLHSF--AGVFCILAIGLLLACLVAALELWWNSNRCH 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7d	NP_001138175.1	None
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250|UniProtKB:Q61627	21..436		52/296 (18%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	50/283 (18%)
		ANF_receptor	41..400	CDD:279440	44/240 (18%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	76/403 (19%)
		Lig_chan	564..841	CDD:278489	56/310 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	930..954

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810