back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7d and GRIA3

DIOPT Version :9

Sequence 1:	NP_001138175.1	Gene:	Ir7d / 7354416	FlyBaseID:	FBgn0259190	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_000819.4	Gene:	GRIA3 / 2892	HGNCID:	4573	Length:	894	Species:	Homo sapiens

Alignment Length:	462	Identity:	80/462 - (17%)
Similarity:	147/462 - (31%)	Gaps:	162/462 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 IVWDIPPYMRINWKSSDPMDGLDGLDGLLLRIVARKMNFTLKLIPNEP-----NGLIGGSSFMNG 274
            :.::|..::||.:|.|...||..|         ||           :|     ||::|  ..:.|
Human   458 LAYEIAKHVRIKYKLSIVGDGKYG---------AR-----------DPETKIWNGMVG--ELVYG 500

  Fly   275 TFTGAYKMLRERRANITIGCAACTPERSTFLEATSPYSQMSYIIVL----QARGG---------Y 326
                        ||:|.:.....|..|...::.:.|:..:...|::    :::.|         |
Human   501 ------------RADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAY 553

  Fly   327 SIYEVMLFPF--EKYTWLLLSTILGLHW-----------------------IVGSRW-------- 358
            .|:..::|.:  ......|:|......|                       |..|.|
Human   554 EIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQ 618

  Fly   359 -------RMPSPILAGWMLWIF--VIRASYEASVFNFI----QNSPVKPSP----------RTLD 400
                   |..|..:.|.:.|.|  :|.:||.|::..|:    ..||::.:.          .|||
Human   619 QGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLD 683

  Fly   401 QALSGGFRFITDHASYRMTLKIPSFQGKTLISAGQPVDVFDALLKAPWKTGAFTSRAFLADHLVR 465
               ||..:.....:...:..|:.|:     :.:.:|              ..||...  ||.:.|
Human   684 ---SGSTKEFFRRSKIAVYEKMWSY-----MKSAEP--------------SVFTKTT--ADGVAR 724

  Fly   466 HRKHRNQLVILAEKIVDNML-----C---------------MYFPHGSYFAWEINKLLFNMRSFG 510
            .||.:.:...|.|..::..:     |               :..|.||.....:|..:..:...|
Human   725 VRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQG 789

  Fly   511 IFQHHSQILAWDNLPTTTDTDTPGKRIHSSTESVATGFAESMSFVVAALNCLMGALCISIVVFGL 575
            :.........:|.          |:......:|.....|.|:|.|......|:|.|.::::|..:
Human   790 LLDKLKNKWWYDK----------GECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALI 844

  Fly   576 ELLSRRR 582
            |...:.|
Human   845 EFCYKSR 851

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.