DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7d and GRIA1

DIOPT Version :9

Sequence 1:	NP_001138175.1	Gene:	Ir7d / 7354416	FlyBaseID:	FBgn0259190	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_001244950.1	Gene:	GRIA1 / 2890	HGNCID:	4571	Length:	916	Species:	Homo sapiens

Alignment Length:	446	Identity:	77/446 - (17%)
Similarity:	152/446 - (34%)	Gaps:	114/446 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 PYMRINWKSSDPMDGLDGLDGLLLRI---VARKMNFTLKL-IPNEPNGLIGGSSFMNGTFTGAYK 281
            ||:.:. |:::..:|.|..:|..:.:   :|:.:.::.:| |.::  |..|........:.|...
Human   428 PYVMLK-KNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSD--GKYGARDPDTKAWNGMVG 489

  Fly   282 MLRERRANITIGCAACTPERSTFLEATSPYSQMSYIIVL----QARGG---------YSIYEVML 333
            .|...||::.:.....|..|...::.:.|:..:...|::    :::.|         |.|:..::
Human   490 ELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIV 554

  Fly   334 FPF--EKYTWLLLSTILGLHW---------------------IVGSRW---------------RM 360
            |.:  ......|:|......|                     |..|.|               |.
Human   555 FAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRS 619

  Fly   361 PSPILAGWMLWIF--VIRASYEASVFNFIQ-NSPVKPSPRTLDQALSGGFRFITDHAS-----YR 417
            .|..:.|.:.|.|  :|.:||.|::..|:. ...|.|.....|.|......:.|..|.     :|
Human   620 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFR 684

  Fly   418 MTLKIPSFQGK-TLISAGQPVDVFDALLKAPWKTGAFTSRAFLADHLVRHRKHRNQLVILAEKIV 481
            .: ||..|:.. |.:.:.:| .||....:               :.::|.||.:.:...|.|..:
Human   685 RS-KIAVFEKMWTYMKSAEP-SVFVRTTE---------------EGMIRVRKSKGKYAYLLESTM 732

  Fly   482 DNML-----C---------------MYFPHGSYFAWEINKLLFNMRSFGIFQHHSQILAWDNLPT 526
            :..:     |               :..|.||.....:|..:..:...|:.........:|.
Human   733 NEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDK--- 794

  Fly   527 TTDTDTPGKRIHSSTESVATGFAESMSFVVAALNCLMGALCISIVVFGLELLSRRR 582
                   |:......:|.....|.|:|.|......|:|.|.::::|..:|...:.|
Human   795 -------GECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSR 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7d	NP_001138175.1	None
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..399	CDD:107385
		ANF_receptor	47..382	CDD:279440
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	66/398 (17%)
		Lig_chan	548..827	CDD:278489	52/305 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810