DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7d and Grid1

DIOPT Version :9

Sequence 1:	NP_001138175.1	Gene:	Ir7d / 7354416	FlyBaseID:	FBgn0259190	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_032192.2	Gene:	Grid1 / 14803	MGIID:	95812	Length:	1009	Species:	Mus musculus

Alignment Length:	761	Identity:	144/761 - (18%)
Similarity:	248/761 - (32%)	Gaps:	279/761 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QHLLEEQLASQISATLQKIFINGLAVYNFGVFISTSYEEMDRDRVILVHQVLNRNLYPP------ 82
            |..|::.....:..:|||:..|...|:. .:|.:...||::|.|..|...:|   |..|
Mouse   179 QSFLDQASRLGLDVSLQKVDKNISHVFT-SLFTTMKTEELNRYRDTLRRAIL---LLSPQGAHSF 239

  Fly    83 -NFPVAVVLASK------MNRKITAQVFTQLLFVQNAEQAIA--IAEGVNRNGLCV-----IVLL 133
             |..|...||||      :|.:|:......|:........:.  |......|..|:     |..|
Mouse   240 INEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCMRNNHRISSL 304

  Fly   134 TSQPERPI--MTKIFTYFMQERYNINVVILVPRLH------------------------------ 166
            ...|:...  |.:|...::.:    :|::|....|
Mouse   305 LCDPQEGYLQMLQISNLYLYD----SVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSM 365

  Fly   167 -------------GVQAF---NVRPYTPTSCSSLEPVEIDIKDGDLWDVFPRRLKNLHGCPLSVI 215
                         ||..|   :..||          |:.:|......:.|.:.::.|
Mouse   366 LDTIKKGHITGLTGVMEFREDSSNPY----------VQFEILGTTYSETFGKDMRKL-------- 412

  Fly   216 VWDIPPYMRINWKSSDPMDGLDG----------LDGLLLRIVA------------------RKMN 252
                     ..|   |...||:|          |.||.|::|.                  |...
Mouse   413 ---------ATW---DSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKG 465

  Fly   253 FTLKL-------------IPNEPNGLIGGSSFMNGTFTGAYKMLRERRANITIGCAACTPERSTF 304
            |::.:             |...|:|.. |....|.::.|....|..:||::.|.....||||.:.
Mouse   466 FSIDVLDALAKALGFKYEIYQAPDGRY-GHQLHNTSWNGMIGELISKRADLAISAITITPERESV 529

  Fly   305 LEATSPYSQMSY-IIVLQARGGYSIYEVMLFPFEKYTWLLLST---ILG---------------- 349
            ::.:..|...|. |::.:.....||:. :..||:...|..::.   ::|
Mouse   530 VDFSKRYMDYSVGILIKKPEEKISIFS-LFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRSQS 593

  Fly   350 -----------LH---WIV-------GSRWRMPSP----ILAGWMLWIFVIRASYEASVFNFIQN 389
                       ||   |||       |....:.|.    ::..|.|:..::.:||.|::..|:..
Mouse   594 ATQPRPSASATLHSAIWIVYGAFVQQGGESSVNSVAMRIVMGSWWLFTLIVCSSYTANLAAFLTV 658

  Fly   390 SPVKPSPRT---LDQALSGGFRFITDHASYRMTLKIPSFQGKTLISAGQPVDVFDALLKAPWKTG 451
            |.:....||   |.:.|...:..:.|.|.|..      |:.|    ...|::. |:.....|:|
Mouse   659 SRMDNPIRTFQDLSKQLEMSYGTVRDSAVYEY------FRAK----GTNPLEQ-DSTFAELWRT- 711

  Fly   452 AFTSRAFLADHLVRHRKHRNQLVILAEKIVDNMLCMYFPHGSY-FAWEINKLLF----------- 504
              .|:...||:.|   .:.::.:..|:|            |:| |.|::..:.:
Mouse   712 --ISKNGGADNCV---SNPSEGIRKAKK------------GNYAFLWDVAVVEYAALTDDDCSVT 759

  Fly   505 ------NMRSFGI-FQHHS--------QILAWDNLPTTTDTDTPGKR-----------IHSSTES 543
                  :.:.:|| .||.|        :||   .|..|.|.|...::           .||||::
Mouse   760 VIGNSISSKGYGIALQHGSPYRDLFSQRIL---ELQDTGDLDVLKQKWWPHTGRCDLTSHSSTQT 821

  Fly   544 VATGFAESMSFVV---AALNCLMG-ALCISIVVFGLELL--SRRRH 583
                  |..|..:   |.:.|::. .|.::.:|..|||.  |.|.|
Mouse   822 ------EGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCH 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7d	NP_001138175.1	None
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269\|PubMed:27418511	21..436		51/294 (17%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	49/281 (17%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	77/403 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810