DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir94d and grik5

DIOPT Version :9

Sequence 1:	NP_001138099.1	Gene:	Ir94d / 7354412	FlyBaseID:	FBgn0259193	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001315085.1	Gene:	grik5 / 798791	ZFINID:	ZDB-GENE-070821-6	Length:	1067	Species:	Danio rerio

Alignment Length:	468	Identity:	84/468 - (17%)
Similarity:	157/468 - (33%)	Gaps:	99/468 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 IERRLDNSTVIFEKRLENLHGYEVPIALGGSSPRLIVYRDLEGKLIFSGPVGNFMKSFEQ----R 220
            :...|.|.::|....|||      |..:     |.|.|::.||...:.|...:.::....    .
Zfish   421 VSETLANKSLIITTILEN------PYVM-----RKINYQEFEGNEQYEGFCVDMLRELSDILKFT 474

  Fly   221 YNCRLVQ------PYPFDESAISPARDLIASVQNGSVQIALGAI---YPQVPYTGYSYPIELMSW 276
            |..:||.      |.| :.|......:||    |....:|:.|.   ..:.....:|.|...:..
Zfish   475 YRIKLVDDGLYGAPEP-NGSWTGMVGELI----NRKADLAVAAFTITSEREKVIDFSKPFMTLGI 534

  Fly   277 CLMMPVP-EEVPHSQLYSMVFSPMAFGITIVAMVLISLTLSMALRLHGYRVSFSEYFLHDSCLR- 339
            .::..|. ...|....:...|||..:...::|.:.:|..|.::.||..|     |::....|||
Zfish   535 SILYRVHIGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLSARLSPY-----EWYNPHPCLRE 594

  Fly   340 -------------------GVLSQSFYEVLRAPALIKAMYLVICLLG------LLITSWYNSYFS 379
                               |...|...|::  |..:...    |:.|      |:|.|.|.:..:
Zfish   595 RRDLLENQYTLGNSLWFPVGGFMQQGSEIM--PRALSTR----CVSGVWWAFTLIIISSYTANLA 653

  Fly   380 TFVTSAPRFPQLTSYESIR-HSNIKIVIWKPEYEMLLFFSENMEKYSSIFQLQEDYKEFLHLRDS 443
            .|:|.......:.|.:.:. .:||:.........|..|.:...:.|..::......:..:.::.:
Zfish   654 AFLTVQRMEVPIESPDDLADQTNIQYGTIHGGSTMTFFMNSRYQTYQRMWNYMYSKQPSVFVKST 718

  Fly   444 -------FDTRYGYMMPMEKWSLMKEQQRVFSSPLFSLQDDLCVFHTVPIVFPMVKNSIFKEPFD 501
                   .:::|.:::.    |.|.|..|..:..|..:..   :..|......|...|.|::...
Zfish   719 EEGIARVVNSKYAFLLE----STMNEYHRSLNCNLTQIGG---LLDTKGYGIGMPLGSPFRDELS 776

  Fly   502 RLILDVTATGLLS----RWRDMSFTEMIKAGQLGLEDRGHPKEFRAMKVGDLIQIWRFVGWMLGL 562
            ..:|.:.....|.    ||.:        .|:...|:....|......:|.:     ||..:.||
Zfish   777 LAVLQLQENNRLEILKRRWWE--------GGKCPKEEDHRAKGLGMENIGGI-----FVVLICGL 828

  Fly   563 ATIVFLLELICFW 575
            ...||:..:...|
Zfish   829 IIAVFVAVMEFVW 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir94d	NP_001138099.1	None
grik5	NP_001315085.1	PBP1_iGluR_Kainate_KA1_2	38..412	CDD:107389
		ANF_receptor	55..392	CDD:279440
		Periplasmic_Binding_Protein_Type_1	<313..383	CDD:299141
		Periplasmic_Binding_Protein_Type_2	427..797	CDD:304360	72/403 (18%)
		Lig_chan	558..828	CDD:278489	48/300 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591853
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930