DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir94d and Grid2

DIOPT Version :9

Sequence 1:	NP_001138099.1	Gene:	Ir94d / 7354412	FlyBaseID:	FBgn0259193	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_077355.2	Gene:	Grid2 / 79220	RGDID:	68368	Length:	1007	Species:	Rattus norvegicus

Alignment Length:	742	Identity:	122/742 - (16%)
Similarity:	234/742 - (31%)	Gaps:	279/742 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ALVLLSPGGDSFYHSLIHHLNRELKIEYVLLLGNFDTTWLDILWQL-PVSVLQIKEHS------- 66
            |:::::|.....:.|.:...|          |..||..|:.|..:: .|.|.::...|
  Rat   230 AILVMNPATAKSFISEVVETN----------LVAFDCHWIIINEEINDVDVQELVRRSIGRLTII 284

  Fly    67 RETYSLLENPS-------HNV-LTIAFVNDSPEDILEILYRNLRMLNTQPVLLVI---------R 114
            |:|:.:.:|.|       |.: .|:....|.....:||  .||.:.:|  |||:.         |
  Rat   285 RQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEI--SNLYIYDT--VLLLANAFHKKLEDR 345

  Fly   115 K-------STIRVNSLLEWCWHHQLLKVV--------------------------AIAQDFMESL 146
            |       |.||.|| ..|.....:|:.:                          .:..::.|.|
  Rat   346 KWHSMASLSCIRKNS-KPWQGGRSMLETIKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEEL 409

  Fly   147 -----IVYSYNPFPVL--QFIERRLDNSTVIFEKRLENLHGYEVPIALGGSSPRLIVYRDLEGKL 204
                 .:..:||...|  ...:::|:|          |:.|..:.:......|.::|..::.||
  Rat   410 GRGVRKLGCWNPVTGLNGSLTDKKLEN----------NMRGVVLRVVTVLEEPFVMVSENVLGK- 463

  Fly   205 IFSGPVGNFMKSFEQRYNCRLVQPYPFDESAISPARDLIASVQNGSVQIALGAIYPQVPYTGYSY 269
                                   |..:...:|    |::.::.|               |.|::|
  Rat   464 -----------------------PKKYQGFSI----DVLDALSN---------------YLGFNY 486

  Fly   270 ------------PIELMSWCLMMPVPEEVPHSQLYSMVFSPMAFGITIVAMVLISLTLSMALRLH 322
                        |.|..:|           :..:..:||.....||:             ||.:.
  Rat   487 EIYVAPDHKYGSPQEDGTW-----------NGLVGELVFKRADIGIS-------------ALTIT 527

  Fly   323 GYR---VSFSEYFLHDSCLRGVLSQSFYEVLRAPALIKAMYL--------VICLLGLLI------ 370
            ..|   |.|:..::..|.  |||.:...:.:...|.:....|        .:.|:|||:
  Rat   528 PDRENVVDFTTRYMDYSV--GVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWL 590

  Fly   371 ------------TSWYNS---YFSTFVTSAPRFPQLTSYESIRHSNIKIVIWKPEYEMLLFFSEN 420
                        |:.|||   .:.:||......|    |.::....:....|.....::..::.|
  Rat   591 NPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVP----YTTLATRMMMGAWWLFALIVISSYTAN 651

  Fly   421 MEKYSSIFQLQEDYKEFLHLRDSFDTRYGYMM--------------PMEKWSLMKEQQRVFSS-- 469
            :..:.:|.:::...:....|....|..||.::              |.|:.|:..:..|:.:.
  Rat   652 LAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPFERDSMYSQMWRMINRSN 716

  Fly   470 ------------------------------PLFSLQDDLCVFHTVPIV-------FPMVKNSIFK 497
                                          ...::.|..|.|:||...       ..:...|.::
  Rat   717 GSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYR 781

  Fly   498 EPFDRLILDVTATG----LLSRWRDMSFTEMIKAGQLGLEDRGHPKE-FRAMKVGDLIQIWRFVG 557
            :.|.:.||::..:|    |..:|       ..|.||..|......|: ..|:.:..|..::..:.
  Rat   782 DVFSQRILELQQSGDMDILKHKW-------WPKNGQCDLYSSVDAKQKGGALDIKSLAGVFCILA 839

  Fly   558 WMLGLATIVFLLELICFWRHKMWQNMK 584
            ..:.|:.::.:||.   |    |...|
  Rat   840 AGIVLSCLIAVLET---W----WSRRK 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir94d	NP_001138099.1	None
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		27/128 (21%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:415822	41/213 (19%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	65/445 (15%)
		Interaction with AP4M1. /evidence=ECO:0000269\|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350000
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840