Protein Alignment Ir94d and Grid2

DIOPT Version :10

• Sequence 1: NP_001138099.1
• Gene: Ir94d / 7354412
• FlyBaseID: FBgn0259193
• Length: 593
• Species: Drosophila melanogaster
• Sequence 2: NP_077355.2
• Gene: Grid2 / 79220
• RGDID: 68368
• Length: 1007
• Species: Rattus norvegicus
• Alignment Length: 742
• Identity: 122/742 - (16%)
• Similarity: 234/742 - (31%)
• Gaps: 279/742 - (37%)

  Fly    10 ALVLLSPGGDSFYHSLIHHLNRELKIEYVLLLGNFDTTWLDILWQL-PVSVLQIKEHS------- 66
            |:::::|.....:.|.:...|          |..||..|:.|..:: .|.|.::...|
  Rat   230 AILVMNPATAKSFISEVVETN----------LVAFDCHWIIINEEINDVDVQELVRRSIGRLTII 284

  Fly    67 RETYSLLENPS-------HNV-LTIAFVNDSPEDILEILYRNLRMLNTQPVLLVI---------R 114
            |:|:.:.:|.|       |.: .|:....|.....:||  .||.:.:|  |||:.         |
  Rat   285 RQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEI--SNLYIYDT--VLLLANAFHKKLEDR 345

  Fly   115 K-------STIRVNSLLEWCWHHQLLKVV--------------------------AIAQDFMESL 146
            |       |.||.|| ..|.....:|:.:                          .:..::.|.|
  Rat   346 KWHSMASLSCIRKNS-KPWQGGRSMLETIKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEEL 409

  Fly   147 -----IVYSYNPFPVL--QFIERRLDNSTVIFEKRLENLHGYEVPIALGGSSPRLIVYRDLEGKL 204
                 .:..:||...|  ...:::|:|          |:.|..:.:......|.::|..::.||
  Rat   410 GRGVRKLGCWNPVTGLNGSLTDKKLEN----------NMRGVVLRVVTVLEEPFVMVSENVLGK- 463

  Fly   205 IFSGPVGNFMKSFEQRYNCRLVQPYPFDESAISPARDLIASVQNGSVQIALGAIYPQVPYTGYSY 269
                                   |..:...:|    |::.::.|               |.|::|
  Rat   464 -----------------------PKKYQGFSI----DVLDALSN---------------YLGFNY 486

  Fly   270 ------------PIELMSWCLMMPVPEEVPHSQLYSMVFSPMAFGITIVAMVLISLTLSMALRLH 322
                        |.|..:|           :..:..:||.....||:             ||.:.
  Rat   487 EIYVAPDHKYGSPQEDGTW-----------NGLVGELVFKRADIGIS-------------ALTIT 527

  Fly   323 GYR---VSFSEYFLHDSCLRGVLSQSFYEVLRAPALIKAMYL--------VICLLGLLI------ 370
            ..|   |.|:..::..|.  |||.:...:.:...|.:....|        .:.|:|||:
  Rat   528 PDRENVVDFTTRYMDYSV--GVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWL 590

  Fly   371 ------------TSWYNS---YFSTFVTSAPRFPQLTSYESIRHSNIKIVIWKPEYEMLLFFSEN 420
                        |:.|||   .:.:||......|    |.::....:....|.....::..::.|
  Rat   591 NPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVP----YTTLATRMMMGAWWLFALIVISSYTAN 651

  Fly   421 MEKYSSIFQLQEDYKEFLHLRDSFDTRYGYMM--------------PMEKWSLMKEQQRVFSS-- 469
            :..:.:|.:::...:....|....|..||.::              |.|:.|:..:..|:.:.
  Rat   652 LAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPFERDSMYSQMWRMINRSN 716

  Fly   470 ------------------------------PLFSLQDDLCVFHTVPIV-------FPMVKNSIFK 497
                                          ...::.|..|.|:||...       ..:...|.::
  Rat   717 GSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYR 781

  Fly   498 EPFDRLILDVTATG----LLSRWRDMSFTEMIKAGQLGLEDRGHPKE-FRAMKVGDLIQIWRFVG 557
            :.|.:.||::..:|    |..:|       ..|.||..|......|: ..|:.:..|..::..:.
  Rat   782 DVFSQRILELQQSGDMDILKHKW-------WPKNGQCDLYSSVDAKQKGGALDIKSLAGVFCILA 839

  Fly   558 WMLGLATIVFLLELICFWRHKMWQNMK 584
            ..:.|:.::.:||.   |    |...|
  Rat   840 AGIVLSCLIAVLET---W----WSRRK 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir94d	NP_001138099.1	None
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424	24..345		27/128 (21%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:471960	41/213 (19%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	65/445 (15%)
		Interaction with AP4M1. /evidence=ECO:0000269|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007