DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir94d and Grik2

DIOPT Version :9

Sequence 1:	NP_001138099.1	Gene:	Ir94d / 7354412	FlyBaseID:	FBgn0259193	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_062182.1	Gene:	Grik2 / 54257	RGDID:	2733	Length:	908	Species:	Rattus norvegicus

Alignment Length:	457	Identity:	82/457 - (17%)
Similarity:	155/457 - (33%)	Gaps:	148/457 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 WHHQLLKVVAIAQDFMESLIVYSYNPFPVLQFIERRLDNSTVIFEKRLENLHGYEVPIALGGSSP 192
            |.||:       .|..:|..|..|   |....:.|.:.:....|:.:...
  Rat   134 WKHQV-------SDNKDSFYVSLY---PDFSSLSRAILDLVQFFKWKTVT--------------- 173

  Fly   193 RLIVYRDLEGKL----IFSGPVGNFMKSFEQRYNCRL-VQPYPFDESAISPARDLIASVQNG--- 249
              :||.|..|.:    :...|         .|||.|| ::..|.|   ...|:.|:..::.|
  Rat   174 --VVYDDSTGLIRLQELIKAP---------SRYNLRLKIRQLPAD---TKDAKPLLKEMKRGKEF 224

  Fly   250 ------SVQIALGAIYPQVPYTGYSYPIELMSWCLMMPVPEEVPH-----SQLYSMVFSPMAFGI 303
                  |.::|.|                ::...|.|.:..|..|     ..|:::...|..:.
  Rat   225 HVIFDCSHEMAAG----------------ILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYS- 272

  Fly   304 TIVAMVLISLTLSMALRLHGYRVSFSEYFLHDSCLRGVLSQSFYEVLRAPALIKAMYLVICLLGL 368
                          .:.:.|:|:..:|    ::.:..::.:...|.|:||....:..|.    |.
  Rat   273 --------------GVNMTGFRILNTE----NTQVSSIIEKWSMERLQAPPKPDSGLLD----GF 315

  Fly   369 LITSWYNSYFSTFVTS--APRFPQLT--SYESIRH----------SNIKIVIWKPEYEMLLFFSE 419
            :.|.....|.:..|.|  ..:|||:|  |.:..||          |.||...|:.....:.|...
  Rat   316 MTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKT 380

  Fly   420 NMEKYSSIFQLQEDYK-EFLHLRDSFDTRYGYMMPMEKWSLMKEQQRVFSSPLFSLQDDLCVFHT 483
            |        .|:.|:. :.:.|::....:.|...|....::.:.|:...::...||.:...:..|
  Rat   381 N--------GLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTT 437

  Fly   484 V---PIVF------PMVKNSIFKEPFDRLILDVTATGLLSRWRDMS----FT---EMIKAGQLGL 532
            :   |.|.      |:..|    :.|:...:|:.        |::|    ||   .:::.|:.|.
  Rat   438 ILEEPYVLFKKSDKPLYGN----DRFEGYCIDLL--------RELSTILGFTYEIRLVEDGKYGA 490

  Fly   533 ED 534
            :|
  Rat   491 QD 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir94d	NP_001138099.1	None
Grik2	NP_062182.1	Periplasmic_Binding_Protein_Type_1	34..414	CDD:299141	65/365 (18%)
		ANF_receptor	52..395	CDD:279440	62/346 (18%)
		Periplasmic_Binding_Protein_Type_2	430..800	CDD:304360	14/75 (19%)
		Glutamate binding. /evidence=ECO:0000269\|PubMed:15721240, ECO:0000269\|PubMed:17115050, ECO:0007744\|PDB:1S50, ECO:0007744\|PDB:1S7Y, ECO:0007744\|PDB:2I0B, ECO:0007744\|PDB:2I0C	516..518
		Lig_chan	562..831	CDD:278489
		Glutamate binding. /evidence=ECO:0000269\|PubMed:15721240, ECO:0000269\|PubMed:17115050, ECO:0007744\|PDB:1S50, ECO:0007744\|PDB:1S7Y, ECO:0007744\|PDB:2I0B, ECO:0007744\|PDB:2I0C	689..690
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350200
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930