DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir94d and gria1b

DIOPT Version :9

Sequence 1:	NP_001138099.1	Gene:	Ir94d / 7354412	FlyBaseID:	FBgn0259193	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_991293.1	Gene:	gria1b / 403044	ZFINID:	ZDB-GENE-020125-2	Length:	917	Species:	Danio rerio

Alignment Length:	256	Identity:	44/256 - (17%)
Similarity:	78/256 - (30%)	Gaps:	98/256 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   368 LLITSWYNSYFSTFVTSAPRFPQLTSYESI--------------------RHSNIKIV--IW--- 407
            |:|.|.|.:..:.|:|.......:.|.|.:                    |.|.|.:.  :|
Zfish   649 LIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDGGSTKEFFRRSKIAVFEKMWSYM 713

  Fly   408 ---------KPEYEMLLFFSENMEKYSSIFQLQEDYKEFLHLRDSFDTR----------YGYMMP 453
                     |...|.::...::..||:  :.|:....|::..|...||.          ||...|
Zfish   714 KSAEPTVFVKTTDEGVVRVRKSKGKYA--YLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATP 776

  Fly   454 MEKWSLMKEQQRVFSSPLFSLQDDLCVFHTVPIVFPMVKNSIFKEPFDRLILDVTATGLLSR--- 515
                                                  |.|..:.|.:..:|.:...|||.:
Zfish   777 --------------------------------------KGSALRNPVNLAVLKLNEQGLLDKLKN 803

  Fly   516 --WRDMSFTEMIKAGQLGLEDRGHPKEFRAMKVGDLIQIWRFVGWMLGLATIVFLLELICF 574
              |.|        .|:.|........:..|:.:.::..::..:...||||.:|.|:| .|:
Zfish   804 KWWYD--------KGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALVE-FCY 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir94d	NP_001138099.1	None
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..387	CDD:107385
		ANF_receptor	41..368	CDD:279440
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	34/210 (16%)
		Lig_chan	536..842	CDD:278489	36/240 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591500
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930