Protein Alignment Ir94d and gria4b

DIOPT Version :10

• Sequence 1: NP_001138099.1
• Gene: Ir94d / 7354412
• FlyBaseID: FBgn0259193
• Length: 593
• Species: Drosophila melanogaster
• Sequence 2: NP_997917.2
• Gene: gria4b / 336069
• ZFINID: ZDB-GENE-030131-8013
• Length: 904
• Species: Danio rerio
• Alignment Length: 838
• Identity: 145/838 - (17%)
• Similarity: 249/838 - (29%)
• Gaps: 336/838 - (40%)

  Fly     2 GQLHLLLVALVLLSPGGDSFYHSLIHHLNRELKIEYVLLLGNFDTTWLDILWQLP--VSVLQIKE 64
            |.||:.|:.....:.|...|    :..|...::...:.||.::|......|:...  .|:||
Zfish   111 GALHISLITPSFPTEGESQF----VLQLRPSIRGALLSLLDHYDWNRFVFLYDTDRGYSILQ--- 168

  Fly    65 HSRETYSLLENPSHN-----VLTIAFVND-SPEDILEILYRNLRMLNTQPVLLVIRKSTIRVNSL 123
                  :::|....|     .:.:...|| |...:||.|.|.      |....||.....|:|::
Zfish   169 ------AIMEKAGQNGWQVSAICVENFNDASYRQLLEDLDRR------QEKTFVIDLEAERLNNM 221

  Fly   124 LEWC--------WHHQLLKVVAI----AQDFME--------SLIVYSYNPFPVLQFIER--RLD- 165
            ||..        .:|.::..:..    .:.||.        .|:.:| ||. |::.::|  :||
Zfish   222 LEQIVSVGKHVKGYHYIMANLGFKDINLERFMHGGANVTGFQLVDFS-NPM-VIKLMQRWNKLDQ 284

  Fly   166 -------------------------------------------------------NSTVIFEKRL 175
                                                                   |..:..|:.|
Zfish   285 REYPGSDAPPKYTSALTYDGVMVMAEAFRNLRRQKVDISRRGIAGDCLANPAAPWNQGIDMERTL 349

  Fly   176 ENLH-----------------GYEVPI-ALGGSSPRLIVYRDLEGKL------------------ 204
            :.:|                 .|.:.: .|..:.||.|.|.:...||
Zfish   350 KQVHLQGLTGNVQFDHYGRRVNYTMDVFELKSNGPRRIGYWNDADKLVLTQDHALLPNETSGMEN 414

  Fly   205 -------IFSGPVGNFMKSFEQRYNCRLVQPYPFD-------------ESAISP-----ARDLIA 244
                   |..||.....|::|........:.|..|             :.:|.|     |||...
Zfish   415 RTVIVTTIMEGPYVMLKKNWEMYEGNEQYEGYCVDLASEIAKHIGFKYKISIVPDGKYGARDPET 479

  Fly   245 SVQNGSV-QIALG----AIYP------QVPYTGYSYPIELMSWCLMMPVPEEVPHSQLYSMVFS- 297
            .:.||.| ::..|    |:.|      :.....:|.|...:...:|:..|::....     |||
Zfish   480 KIWNGMVGELVYGKAEIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPG-----VFSF 539

  Fly   298 --PMAFGI---TIVAMVLISLTLSMALRLHGYRVSFSEYFLHDSCLR---------------GVL 342
              |:|:.|   .:.|.:.:|:.|.:..|       ||.|..|.....               |:.
Zfish   540 LDPLAYEIWMCIVFAYIGVSVVLFLVSR-------FSPYEWHTEEPEEGTDGLPSDQPPNEFGIF 597

  Fly   343 SQSFYEV---LRAPALIKAMYLVICLLG-------LLITSWYNSYFSTFVTSAPRFPQLTSYESI 397
            :..::.:   ::....|....|...::|       |:|.|.|.:..:.|:|.......:.|.|.:
Zfish   598 NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL 662

  Fly   398 --------------------RHSNIKIVIWKPEYEMLLFFSENME-------------------- 422
                                |.|.|.:      ||.:..:.::.|
Zfish   663 AKQTDIAYGTLDSGSTKEFFRRSKIAV------YEKMWSYMKSAEPTVFTKTTAEGVARVRKSKG 721

  Fly   423 KYSSIFQLQEDYKEFLHLRDSFDTR----------YGYMMPMEKWSLMKEQQRVFSSPLFSLQDD 477
            ||:  |.|:....|:...|...||.          ||...|
Zfish   722 KYA--FLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATP------------------------ 760

  Fly   478 LCVFHTVPIVFPMVKNSIFKEPFDRLILDVTATGLLSR-----WRDMSFTEMIKAGQLGLEDRGH 537
                          |.|..:...:..:|.:...|||.:     |.|        .|:.|....|.
Zfish   761 --------------KGSQLRSAVNLAVLKLNEQGLLDKLKNKWWYD--------KGECGSGGGGE 803

  Fly   538 -PKEFRAMKVGDLIQIWRFVGWMLGLATIVFLLELICFWRHKMWQNMKYMF---CRNK 591
             .|..:|:.:.::..::..:...||||.:|.|:| .|:......:.||..|   .|||
Zfish   804 KDKSSQALSLSNVAGVFYILVGGLGLAMLVALIE-FCYKSRNEAKRMKLTFTEAMRNK 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir94d	NP_001138099.1	None
gria4b	NP_997917.2	Periplasmic_Binding_Protein_type1	28..400	CDD:471960	53/309 (17%)
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	73/444 (16%)
		Lig_chan	546..826	CDD:459656	51/340 (15%)