DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir94d and Gria4

DIOPT Version :9

Sequence 1:	NP_001138099.1	Gene:	Ir94d / 7354412	FlyBaseID:	FBgn0259193	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001106655.1	Gene:	Gria4 / 29629	RGDID:	61863	Length:	902	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	98/554 - (17%)
Similarity:	169/554 - (30%)	Gaps:	193/554 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 MESLIVYSYNPFPVLQFIERRLDNSTVIFEKRLENLHGYEVPIALGGSSPRLIVYRD----LEGK 203
            |:.|::  ....|.|......::|.||:....:|              || .::|:.    .||.
  Rat   393 MDKLVL--IQDMPTLGNDTAAIENRTVVVTTIME--------------SP-YVMYKKNHEMFEGN 440

  Fly   204 LIFSG----PVGNFMKSFEQRYNCRLVQPYPFDESAISPARDLIASVQNGSV-QIALG----AIY 259
            ..:.|    ......|....:|...:|....:.      |||....:.||.| ::..|    ||.
  Rat   441 DKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYG------ARDADTKIWNGMVGELVYGKAEIAIA 499

  Fly   260 P------QVPYTGYSYPIELMSWCLMMPVPEEVPHSQLYSMVFS---PMAFGI---TIVAMVLIS 312
            |      :.....:|.|...:...:|:..|::....     |||   |:|:.|   .:.|.:.:|
  Rat   500 PLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPG-----VFSFLDPLAYEIWMCIVFAYIGVS 559

  Fly   313 LTLSMALRLHGYRVSFSEYFLHDSCLR--------------GVLSQSFYEV---LRAPALIKAMY 360
            :.|.:..|       ||.|..|.....              |:.:..::.:   ::....|....
  Rat   560 VVLFLVSR-------FSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRS 617

  Fly   361 LVICLLG-------LLITSWYNSYFSTFVTSAPRFPQLTSYESI--------------------R 398
            |...::|       |:|.|.|.:..:.|:|.......:.|.|.:                    |
  Rat   618 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFR 682

  Fly   399 HSNIKIVIWKPEYEMLLFFSENME------------------KYSSIFQLQEDYKEFLHLRDSFD 445
            .|.|.:      ||.:..:..:.|                  |....|.|:....|::..|...|
  Rat   683 RSKIAV------YEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCD 741

  Fly   446 TR----------YGYMMPMEKWSLMKEQQRVFSSPLFSLQDDLCVFHTVPIVFPMVKNSIFKEPF 500
            |.          ||...|                                      |.|..:...
  Rat   742 TMKVGGNLDSKGYGVATP--------------------------------------KGSSLRNAV 768

  Fly   501 DRLILDVTATGLLSR-----WRDMSFTEMIKAGQLGLEDRGHPKEFRAMKVGDLIQIWRFVGWML 560
            :..:|.:...|||.:     |.|        .|:.|........:..|:.:.::..::..:...|
  Rat   769 NLAVLKLNEQGLLDKLKNKWWYD--------KGECGSGGGDSKDKTSALSLSNVAGVFYILVGGL 825

  Fly   561 GLATIVFLLELICFWRHKMWQNMKYMF---CRNK 591
            |||.:|.|:| .|:......:.||..|   .|||
  Rat   826 GLAMLVALIE-FCYKSRAEAKRMKLTFSEAIRNK 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir94d	NP_001138099.1	None
Gria4	NP_001106655.1	PBP1_iGluR_AMPA_GluR4	28..398	CDD:107383	2/4 (50%)
		ANF_receptor	39..380	CDD:279440
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	78/465 (17%)
		Lig_chan	546..825	CDD:278489	48/337 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350173
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930