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Protein Alignment Ir94d and GRIN2D

DIOPT Version :9

Sequence 1:	NP_001138099.1	Gene:	Ir94d / 7354412	FlyBaseID:	FBgn0259193	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_000827.2	Gene:	GRIN2D / 2906	HGNCID:	4588	Length:	1336	Species:	Homo sapiens

Alignment Length:	645	Identity:	114/645 - (17%)
Similarity:	205/645 - (31%)	Gaps:	266/645 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 WHHQLLKVVA-----IAQDFMESLIVYSYNPFPVLQFIERRLDNSTVIFEKRLENLHGYEVPIAL 187
            |...|.:.||     :|:.....|..|.:  .|.|.. :.|..|.|    .|.|:||.|.:.|..
Human   312 WRDDLARRVAAGVAVVARGAQALLRDYGF--LPELGH-DCRAQNRT----HRGESLHRYFMNITW 369

  Fly   188 GGS-----------SPRLIVY---RDLEGKLIFSGPVGNFMKSFEQ-----------RYNCRLVQ 227
            ...           :|.|:|.   ||...:::         .|:||           ||. |.:|
Human   370 DNRDYSFNEDGFLVNPSLVVISLTRDRTWEVV---------GSWEQQTLRLKYPLWSRYG-RFLQ 424

  Fly   228 PYPFDESAISPARDL-IASVQNGSVQIALGAIYPQVPYTGYSYPIELMSWCLMMPVPEEVPHSQL 291
            |       :...:.| :|:::.....|    :.|..|.:|         .|:...||   ..|||
Human   425 P-------VDDTQHLTVATLEERPFVI----VEPADPISG---------TCIRDSVP---CRSQL 466

  Fly   292 YSMVFSP------------MAFGITIVAMVLISLTLSMALRL-----HGYRVSFSEYFLHDSCLR 339
             :...||            ..|.|.|:..:..::..|..|.|     ||.::        |....
Human   467 -NRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKI--------DGVWN 522

  Fly   340 GVLSQSFYE---------------------------------VLR--------------APALIK 357
            |::.:.||:                                 |.|              :|| :.
Human   523 GMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPA-VW 586

  Fly   358 AMYLVICLLGLLITSWYNSYFS-------------------------------TFVTSAP-RFPQ 390
            .|..|:||..:.:|.:...|.|                               .|..|.| ..|:
Human   587 VMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPR 651

  Fly   391 LTSYESIRHSNIKIVIWKPEYEMLLF---FSENMEKYSSIFQLQEDYKEFL-------------- 438
            .|:      |.|.:::|  .:..::|   ::.|:    :.|.:||:|.:.:
Human   652 GTT------SKIMVLVW--AFFAVIFLASYTANL----AAFMIQEEYVDTVSGLSDRKFQRPQEQ 704

  Fly   439 ----------------HLRDSFDTRYGYMM----PMEKWSLM-----KEQQRVFSSPLFSL---Q 475
                            ::|.::...:.||:    |..:.:|.     |....::.:.:.:.   :
Human   705 YPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARK 769

  Fly   476 DDLC---------VFHTVPIVFPMVKNSIFKEPFDRLILDVTATGLLSRWRDMSFTEMIKAGQLG 531
            |:.|         ||.|......:.|.|.:|.|.|..:|.......:         ||::  :|.
Human   770 DEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEI---------EMLE--RLW 823

  Fly   532 LEDRGHPKEFRAMK----VGDLIQIWRFVGWMLGLATIVFLLELICFWR--------HKM 579
            |....|..:...|.    :.::..::..:...:||:.:||..|.:.:||        |:|
Human   824 LSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRM 883

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.