DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir94d and GRIK5

DIOPT Version :9

Sequence 1:	NP_001138099.1	Gene:	Ir94d / 7354412	FlyBaseID:	FBgn0259193	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens

Alignment Length:	467	Identity:	86/467 - (18%)
Similarity:	161/467 - (34%)	Gaps:	96/467 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 IERRLDNSTVIFEKRLENLHGYEVPIALGGSSPRLIVYRDLEGKLIFSGPVGNFMKSFEQ----R 220
            :.:.|.|.|::....|||.:....|           .::.|.|...|.|...:.::...:    |
Human   408 LSQTLANKTLVVTTILENPYVMRRP-----------NFQALSGNERFEGFCVDMLRELAELLRFR 461

  Fly   221 YNCRLVQ------PYPFDESAISPARDLIASVQNGSVQIALGAIYPQ-VPYTGYSYPIELMSWCL 278
            |..|||:      |.| :.|......:|| :.|...:.:|...|..: .....:|.|...:...:
Human   462 YRLRLVEDGLYGAPEP-NGSWTGMVGELI-NRQKADLAVAAFTITAEREKVIDFSKPFMTLGISI 524

  Fly   279 MMPV-PEEVPHSQLYSMVFSPMAFGITIVAMVLISLTLSMALRLHGYRVSFSEYFLHDSCLR--- 339
            :..| ....|....:...|||..:...::|.:.:|..|.:|.||..|     |::....|||
Human   525 LYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPY-----EWYNPHPCLRARP 584

  Fly   340 -----------------GVLSQSFYEVLRAPALIKAMYLVICLLG------LLITSWYNSYFSTF 381
                             |...|...|::  |..:...    |:.|      |:|.|.|.:..:.|
Human   585 HILENQYTLGNSLWFPVGGFMQQGSEIM--PRALSTR----CVSGVWWAFTLIIISSYTANLAAF 643

  Fly   382 VT-SAPRFPQLTSYESIRHSNIKIVIWKPEYEMLLFFSENMEKYSSIFQLQEDYKEFLHLRDS-- 443
            :| .....|..::.:....:||:.........|..|.:...:.|..::...:..:..:.::.:
Human   644 LTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEE 708

  Fly   444 -----FDTRYGYMMPMEKWSLMKEQQRVFSSPLFSLQDDLCVFHTVPIVFPMVKNSIFKEPFDRL 503
                 .::||.:::.    |.|.|..|..:..|..:..   :..|......|...|.|::.....
Human   709 GIARVLNSRYAFLLE----STMNEYHRRLNCNLTQIGG---LLDTKGYGIGMPLGSPFRDEITLA 766

  Fly   504 ILDVTATGLLSRWRDMSFTEMIK-----AGQLGLEDRGHPKEFRAMKVGDLIQIWRFVGWMLGLA 563
            ||.:.....|         |::|     .|:...|:....|......:|.:     |:..:.||.
Human   767 ILQLQENNRL---------EILKRKWWEGGRCPKEEDHRAKGLGMENIGGI-----FIVLICGLI 817

  Fly   564 TIVFLLELICFW 575
            ..||:..:...|
Human   818 IAVFVAVMEFIW 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir94d	NP_001138099.1	None
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389
		ANF_receptor	42..379	CDD:279440
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	75/410 (18%)
		Lig_chan	546..816	CDD:278489	50/301 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156266
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840