Protein Alignment Ir94d and GRIK4

DIOPT Version :10

• Sequence 1: NP_001138099.1
• Gene: Ir94d / 7354412
• FlyBaseID: FBgn0259193
• Length: 593
• Species: Drosophila melanogaster
• Sequence 2: NP_055434.2
• Gene: GRIK4 / 2900
• HGNCID: 4582
• Length: 956
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 92/538 - (17%)
• Similarity: 167/538 - (31%)
• Gaps: 184/538 - (34%)

  Fly   128 WHHQLLKVVAIAQDFMESLIVYSYNPFPVLQFIERRLDNSTVIFEKRLENLHGYEVPIALGGSSP 192
            ||        :|:.......:|:.|       |...|.|:|::....|||.:     :.|.|:
Human   392 WH--------VAEGLSMDSHLYASN-------ISDTLFNTTLVVTTILENPY-----LMLKGN-- 434

  Fly   193 RLIVYRDLEGKLIFSGPVGNFMKSFEQ----RYNCRLVQP--YPFDES----------------- 234
                ::::||...:.|...:.:|...:    .|..|||..  |...|:
Human   435 ----HQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKAD 495

  Fly   235 ------AISPARDLIASVQNGSVQIALGAIY----PQVPYTGYSYPIELMSWCLMMPVPEEVPHS 289
                  .|:..|:.:.......:.:.:..:|    .:.|  ||
Human   496 LAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKP--GY---------------------- 536

  Fly   290 QLYSMV--FSPMAFGITIVAMVLISLTLSMALRLHGYRVSFSEYFLHDSCLRGVLSQSFYEVLRA 352
              :|.:  |||..:...::|.:.:|..|.:..||..|     |::....|.:|          |.
Human   537 --FSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPY-----EWYSPHPCAQG----------RC 584

  Fly   353 PALIKAMYLVICLLGLLITSWY--NSYFSTFVTSAPRFPQLTSYESIRHSNIKIVIWKPEYEMLL 415
            ..|:....|...|       |:  ..:.....|.|||        ::....:..|.|.....::.
Human   585 NLLVNQYSLGNSL-------WFPVGGFMQQGSTIAPR--------ALSTRCVSGVWWAFTLIIIS 634

  Fly   416 FFSENMEKYSSIFQLQEDYKEFLHLRDSFDTRYG---------------YMMPMEKWSLM-KEQQ 464
            .::.|:..:.::.::....:....|.|.....||               |......|:.| .:|.
Human   635 SYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQP 699

  Fly   465 RVF-------------SSPLFSLQDDLCVFH---------------TVPIVFPMVKNSIFKEPFD 501
            .||             |:..|.|:..:..::               |......|...|:|::.||
Human   700 SVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFD 764

  Fly   502 RLILDVTATGLLSRWRDMSFTEMIK-----AGQLGLEDRGHPKEFRAMKVGDLIQIWRFVGWMLG 561
            ..||.:.....|         |::|     .|:...|:....|......:|.:     ||..:.|
Human   765 LAILQLQENNRL---------EILKRKWWEGGKCPKEEDHRAKGLGMENIGGI-----FVVLICG 815

  Fly   562 LATIVFLLELICFW--RH 577
            |...:|:..|...|  ||
Human   816 LIVAIFMAMLEFLWTLRH 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir94d	NP_001138099.1	None
GRIK4	NP_055434.2	PBP1_iGluR_Kainate_KA1_2	24..402	CDD:380616	3/17 (18%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	72/445 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956