DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir94d and GRID1

DIOPT Version :9

Sequence 1:	NP_001138099.1	Gene:	Ir94d / 7354412	FlyBaseID:	FBgn0259193	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens

Alignment Length:	698	Identity:	127/698 - (18%)
Similarity:	242/698 - (34%)	Gaps:	201/698 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ALVLLSP-GGDSFYHSLIH-----------HLNRELKIEYVLLLGNFDTTWLDILWQLPVSVLQI 62
            |::|||| |..||.:..:.           .:|.|:....:|.|.:.....:.::.|:..|....
Human   227 AILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDN 291

  Fly    63 KEHSRETY---SLLENPSHNVLTI-----AFVNDSPEDILEILYRNL--RMLNTQPVLLVIRKST 117
            ::.:|..:   |||.:|....|.:     .::.||...:....:|.|  |..::...|..|||||
Human   292 QKCTRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKST 356

  Fly   118 IRVN---SLLEWCWHHQLLKVVAIAQDFMESLIVYSYNPFPVLQFIERRLDNSTVIFEKRLENLH 179
            ...|   |:|:......:..:..: .:|.|.    |.||:...:.:......:   |.|.:..|.
Human   357 KPWNGGRSMLDTIKKGHITGLTGV-MEFRED----SSNPYVQFEILGTTYSET---FGKDMRKLA 413

  Fly   180 GYEVPIALGGSSPRLIVYRDLEGKLIFSGPVGNFMKSFEQRYNCRLVQPYPFDESAISPARDLIA 244
            .::....|.||              :...|:|:.::....:....|.:|:      :..|.:::.
Human   414 TWDSEKGLNGS--------------LQERPMGSRLQGLTLKVVTVLEEPF------VMVAENILG 458

  Fly   245 S---VQNGSVQI------ALGAIYP--QVPYTGYSYPIELMSWCLMMPVPEEVPHSQLYSMVFSP 298
            .   .:..|:.:      |||..|.  |.|...|.:.:...||            :.:...:.|.
Human   459 QPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSW------------NGMIGELISK 511

  Fly   299 MAFGITIVAMVLISLTLSMALRLHGYRVSFSEYFLHDSCLRGVLSQSFYE-----VLRAP---AL 355
            .| .:.|.|:.:.....|:        |.||:.::..|.  |:|.:...|     .|.||   |:
Human   512 RA-DLAISAITITPERESV--------VDFSKRYMDYSV--GILIKKPEEKISIFSLFAPFDFAV 565

  Fly   356 IKAMYLVICLLGLLITSWYNSYFSTFV-----------TSAPR-----------------FPQLT 392
            ...:...|.::|:||          ||           .:.||                 |.|..
Human   566 WACIAAAIPVVGVLI----------FVLNRIQAVRAQSAAQPRPSASATLHSAIWIVYGAFVQQG 620

  Fly   393 SYESIRHSNIKIVI---WKPEYEMLLFFSENMEKYSSIFQLQEDYKEFLHLRDSFDTRYGYMM-- 452
            ...|:....::||:   |.....:...::.|:..:.::.::....:.|..|....:..||.:.
Human   621 GESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDS 685

  Fly   453 ------------PMEKWSLMKEQQRVF----------SSP----------------------LFS 473
                        |:|:.|...|..|..          |||                      ..:
Human   686 AVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAA 750

  Fly   474 LQDDLCVFHTVPIV----------FPMVKNSIFKEPFDRLILDVTATGLLSRWRDMSFTEMIKAG 528
            |.||.|   :|.::          ..:...|.:::.|.:.||::..||.|...:...:..|   |
Human   751 LTDDDC---SVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHM---G 809

  Fly   529 QLGLEDRGHPK-EFRAMKVGDLIQIWRFVGWMLGLATIVFLLELICFW 575
            :..|......: :.:::|:.....::..:...|.||.:|..|||  :|
Human   810 RCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALEL--WW 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir94d	NP_001138099.1	None
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		47/230 (20%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	43/203 (21%)
		ANF_receptor	41..400	CDD:279440	39/177 (22%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	68/411 (17%)
		Lig_chan	564..841	CDD:278489	44/292 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155873
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840