DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir94d and GRIA4

DIOPT Version :10

Sequence 1:NP_001138099.1 Gene:Ir94d / 7354412 FlyBaseID:FBgn0259193 Length:593 Species:Drosophila melanogaster
Sequence 2:NP_000820.4 Gene:GRIA4 / 2893 HGNCID:4574 Length:902 Species:Homo sapiens


Alignment Length:570 Identity:103/570 - (18%)
Similarity:174/570 - (30%) Gaps:219/570 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 RRLDNSTVIFEKRLENLHGYEVPIALGGSSPRLIVYRDLEGKLIFSGPV---GNFMKSFEQR--- 220
            ||::.:..:||              |..:.||.:.|.:...||:....|   ||...:.|.|   
Human   368 RRVNYTMDVFE--------------LKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVV 418

  Fly   221 YNCRLVQPYPFDES--------------------------------AISP-----ARDLIASVQN 248
            ....:..||...:.                                ||.|     |||....:.|
Human   419 VTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWN 483

  Fly   249 GSV-QIALG----AIYP------QVPYTGYSYPIELMSWCLMMPVPEEVPHSQLYSMVFS---PM 299
            |.| ::..|    ||.|      :.....:|.|...:...:|:..|::....     |||   |:
Human   484 GMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPG-----VFSFLDPL 543

  Fly   300 AFGI---TIVAMVLISLTLSMALRLHGYRVSFSEYFLHDSCLR--------------GVLSQSFY 347
            |:.|   .:.|.:.:|:.|.:..|       ||.|..|.....              |:.:..::
Human   544 AYEIWMCIVFAYIGVSVVLFLVSR-------FSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWF 601

  Fly   348 EV---LRAPALIKAMYLVICLLG-------LLITSWYNSYFSTFVTSAPRFPQLTSYESI----- 397
            .:   ::....|....|...::|       |:|.|.|.:..:.|:|.......:.|.|.:     
Human   602 SLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTE 666

  Fly   398 ---------------RHSNIKIVIWKPEYEMLLFFSENME------------------KYSSIFQ 429
                           |.|.|.:      ||.:..:..:.|                  |....|.
Human   667 IAYGTLDSGSTKEFFRRSKIAV------YEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFL 725

  Fly   430 LQEDYKEFLHLRDSFDTR----------YGYMMPMEKWSLMKEQQRVFSSPLFSLQDDLCVFHTV 484
            |:....|::..|...||.          ||...|                               
Human   726 LESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATP------------------------------- 759

  Fly   485 PIVFPMVKNSIFKEPFDRLILDVTATGLLSR-----WRDMSFTEMIKAGQLGLEDRGHPKEFRAM 544
                   |.|..:.|.:..:|.::..|:|.:     |.|        .|:.|.:|.|...:..|:
Human   760 -------KGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYD--------KGECGPKDSGSKDKTSAL 809

  Fly   545 KVGDLIQIWRFVGWMLGLATIVFLLELICFWRHKMWQNMKYMF---CRNK 591
            .:.::..::..:...||||.:|.|:| .|:......:.||..|   .|||
Human   810 SLSNVAGVFYILVGGLGLAMLVALIE-FCYKSRAEAKRMKLTFSEAIRNK 858

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir94dNP_001138099.1 None
GRIA4NP_000820.4 PBP1_iGluR_AMPA_GluR4 28..400 CDD:380611 10/45 (22%)
PBP2_iGluR_AMPA_GluR4 414..795 CDD:270445 71/444 (16%)

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