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Protein Alignment Ir94d and GRIA4

DIOPT Version :9

Sequence 1:	NP_001138099.1	Gene:	Ir94d / 7354412	FlyBaseID:	FBgn0259193	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_000820.4	Gene:	GRIA4 / 2893	HGNCID:	4574	Length:	902	Species:	Homo sapiens

Alignment Length:	570	Identity:	103/570 - (18%)
Similarity:	174/570 - (30%)	Gaps:	219/570 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 RRLDNSTVIFEKRLENLHGYEVPIALGGSSPRLIVYRDLEGKLIFSGPV---GNFMKSFEQR--- 220
            ||::.:..:||              |..:.||.:.|.:...||:....|   ||...:.|.|
Human   368 RRVNYTMDVFE--------------LKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVV 418

  Fly   221 YNCRLVQPYPFDES--------------------------------AISP-----ARDLIASVQN 248
            ....:..||...:.                                ||.|     |||....:.|
Human   419 VTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWN 483

  Fly   249 GSV-QIALG----AIYP------QVPYTGYSYPIELMSWCLMMPVPEEVPHSQLYSMVFS---PM 299
            |.| ::..|    ||.|      :.....:|.|...:...:|:..|::....     |||   |:
Human   484 GMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPG-----VFSFLDPL 543

  Fly   300 AFGI---TIVAMVLISLTLSMALRLHGYRVSFSEYFLHDSCLR--------------GVLSQSFY 347
            |:.|   .:.|.:.:|:.|.:..|       ||.|..|.....              |:.:..::
Human   544 AYEIWMCIVFAYIGVSVVLFLVSR-------FSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWF 601

  Fly   348 EV---LRAPALIKAMYLVICLLG-------LLITSWYNSYFSTFVTSAPRFPQLTSYESI----- 397
            .:   ::....|....|...::|       |:|.|.|.:..:.|:|.......:.|.|.:
Human   602 SLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTE 666

  Fly   398 ---------------RHSNIKIVIWKPEYEMLLFFSENME------------------KYSSIFQ 429
                           |.|.|.:      ||.:..:..:.|                  |....|.
Human   667 IAYGTLDSGSTKEFFRRSKIAV------YEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFL 725

  Fly   430 LQEDYKEFLHLRDSFDTR----------YGYMMPMEKWSLMKEQQRVFSSPLFSLQDDLCVFHTV 484
            |:....|::..|...||.          ||...|
Human   726 LESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATP------------------------------- 759

  Fly   485 PIVFPMVKNSIFKEPFDRLILDVTATGLLSR-----WRDMSFTEMIKAGQLGLEDRGHPKEFRAM 544
                   |.|..:.|.:..:|.::..|:|.:     |.|        .|:.|.:|.|...:..|:
Human   760 -------KGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYD--------KGECGPKDSGSKDKTSAL 809

  Fly   545 KVGDLIQIWRFVGWMLGLATIVFLLELICFWRHKMWQNMKYMF---CRNK 591
            .:.::..::..:...||||.:|.|:| .|:......:.||..|   .|||
Human   810 SLSNVAGVFYILVGGLGLAMLVALIE-FCYKSRAEAKRMKLTFSEAIRNK 858

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.