back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir94d and GRIA2

DIOPT Version :9

Sequence 1:	NP_001138099.1	Gene:	Ir94d / 7354412	FlyBaseID:	FBgn0259193	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens

Alignment Length:	739	Identity:	135/739 - (18%)
Similarity:	233/739 - (31%)	Gaps:	253/739 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DSFYHSLIHHLNRELKIE----------------------------YVLLLGNFDTTWLDIL--- 52
            |..|.||...|  |||.|                            |..::.|...|..|:|
Human   189 DEMYRSLFQDL--ELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQ 251

  Fly    53 -WQLPVSVLQIKEHSR-------ETYSLLEN---PSHNVLTIAFVNDSPEDILEILYRNLRMLNT 106
             ....||..||.::..       |.:|.||.   |..:..||.:.:....|.::::....|.|..
Human   252 FGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRK 316

  Fly   107 QPVLLVIRKST--IRVNSLLEWCWHHQLLKVVAIAQDFMESL------------IVYSYNPFPVL 157
            |.:.:..|.:.  ...|..:.|....::.:  |:.|..:|.|            |.|:.|...:.
Human   317 QRIEISRRGNAGDCLANPAVPWGQGVEIER--ALKQVQVEGLSGNIKFDQNGKRINYTINIMELK 379

  Fly   158 QFIERR-------------------------LDNSTVIFEKRLENLHGYEVPIALGGSSPRLIVY 197
            ....|:                         |:|.||:....||              ||.:::.
Human   380 TNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILE--------------SPYVMMK 430

  Fly   198 RD---LEGKLIFSG----PVGNFMKSFEQRYNCRLVQPYPFDESAISPARDLIASVQNGSV-QIA 254
            ::   |||...:.|    ......|....:|...:|....:.      |||....:.||.| ::.
Human   431 KNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYG------ARDADTKIWNGMVGELV 489

  Fly   255 LG----AIYP------QVPYTGYSYPIELMSWCLMMPVPEEVPHSQLYSMVFS---PMAFGI--- 303
            .|    ||.|      :.....:|.|...:...:|:..|::....     |||   |:|:.|
Human   490 YGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPG-----VFSFLDPLAYEIWMC 549

  Fly   304 TIVAMVLISLTLSMALRLHGYR---------------VSFSEYFLHDSC--LRGVLSQSFYEVLR 351
            .:.|.:.:|:.|.:..|...|.               .|.:|:.:.:|.  ..|...|...::
Human   550 IVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDI-- 612

  Fly   352 APALIKAMYL--VICLLGLLITSWYNSYFSTFVTSAPRFPQLTSYESI----------------- 397
            :|..:....:  |.....|:|.|.|.:..:.|:|.......:.|.|.:
Human   613 SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTK 677

  Fly   398 ---RHSNI----KIVIWKPEYEMLLFFSENME----------KYSSIFQLQEDYKEFLHLRDSFD 445
               |.|.|    |:..:....|..:|.....|          ||:  :.|:....|::..|...|
Human   678 EFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYA--YLLESTMNEYIEQRKPCD 740

  Fly   446 TR----------YGYMMPMEKWSLMKEQQRVFSSPLFSLQDDLCVFHTVPIVFPMVKNSIFKEPF 500
            |.          ||...|                                      |.|..:.|.
Human   741 TMKVGGNLDSKGYGIATP--------------------------------------KGSSLRTPV 767

  Fly   501 DRLILDVTATGLLSR-----WRDMSFTEMIKAGQLGLEDRGHPKEFRAMKVGDLIQIWRFVGWML 560
            :..:|.::..|:|.:     |.|        .|:.|.:|.|..::..|:.:.::..::..:...|
Human   768 NLAVLKLSEQGVLDKLKNKWWYD--------KGECGAKDSGSKEKTSALSLSNVAGVFYILVGGL 824

  Fly   561 GLATIVFLLELICFWRHKMWQNMK 584
            |||.:|.|:| .|:......:.||
Human   825 GLAMLVALIE-FCYKSRAEAKRMK 847

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.