Protein Alignment Ir94d and GRIA1

DIOPT Version :9

• Sequence 1: NP_001138099.1
• Gene: Ir94d / 7354412
• FlyBaseID: FBgn0259193
• Length: 593
• Species: Drosophila melanogaster
• Sequence 2: NP_001244950.1
• Gene: GRIA1 / 2890
• HGNCID: 4571
• Length: 916
• Species: Homo sapiens
• Alignment Length: 819
• Identity: 134/819 - (16%)
• Similarity: 251/819 - (30%)
• Gaps: 309/819 - (37%)

  Fly     2 GQLHLLLVALVLLSPGGDSF----YHSLIHHLNRELKIEYVLLLGNFDTTWLDILWQLPVSVLQI 62
            |.||:..:.        .||    .:..:..|..||:...:.::.::.       ||..|.:...
Human   112 GALHVCFIT--------PSFPVDTSNQFVLQLRPELQDALISIIDHYK-------WQKFVYIYDA 161

  Fly    63 KEHSRETYSLLENPSHNVLTIAFVN--DSPEDILEILYRNLRMLNTQPVLLVIRKSTIRVNSLL- 124
            .........:|:..:.....:..||  .:.|:...:|:::|.....:  |:|:...:.|:|::|
Human   162 DRGLSVLQKVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKER--LVVVDCESERLNAILG 224

  Fly   125 -------EWCWHHQLLKVVAI----AQDFMES--------LIVYSYN-PFPVLQFIER------- 162
                   ....:|.:|..:..    ...|.||        |:.|:.. |..::|..:.
Human   225 QIIKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHT 289

  Fly   163 RLD------------NSTVIFEKRLENLHGYEVPIALGGSSPRLI------------VYRDLEGK 203
            |:|            :...:..:..::|....:.|:..|::...:            :.|.|: :
Human   290 RVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQ-Q 353

  Fly   204 LIFSGPVGNFM---KSFEQRYNCRLVQP----------YPFDESAISPARDLIASVQNGSVQ--- 252
            :.|.|..||..   |.....|...:::.          :..|:..:..|.|..|...|.|||
Human   354 VRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRT 418

  Fly   253 -------------------------------IALGAIYPQVPYTGYSYPIELMS----------- 275
                                           :.|.|...:  :.||||.:|::|
Human   419 YIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAK--HVGYSYRLEIVSDGKYGARDPDT 481

  Fly   276 --WCLMMP------------------VPEEV-----PHSQL-YSM-----------VFS---PMA 300
              |..|:.                  |.|||     |...| .|:           |||   |:|
Human   482 KAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLA 546

  Fly   301 FGI---TIVAMVLISLTLSMALRLHGYRVSFSEYFLHDSCLR--------------GVLSQSFYE 348
            :.|   .:.|.:.:|:.|.:..|       ||.|..|.....              |:.:..::.
Human   547 YEIWMCIVFAYIGVSVVLFLVSR-------FSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFS 604

  Fly   349 V---LRAPALIKAMYLVICLLG-------LLITSWYNSYFSTFVTSAPRFPQLTSYESI------ 397
            :   ::....|....|...::|       |:|.|.|.:..:.|:|.......:.|.|.:
Human   605 LGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEI 669

  Fly   398 --------------RHSNIKIV--IW------------KPEYEMLLFFSENMEKYSSIFQLQEDY 434
                          |.|.|.:.  :|            :...|.::...::..||:  :.|:...
Human   670 AYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYA--YLLESTM 732

  Fly   435 KEFLHLRDSFDTR----------YGYMMPMEKWSLMKEQQRVFSSPLFSLQDDLCVFHTVPIVFP 489
            .|::..|...||.          ||...|
Human   733 NEYIEQRKPCDTMKVGGNLDSKGYGIATP------------------------------------ 761

  Fly   490 MVKNSIFKEPFDRLILDVTATGLLSR-----WRDMSFTEMIKAGQLGLEDRGHPKEFRAMKVGDL 549
              |.|..:.|.:..:|.:...|||.:     |.|        .|:.|........:..|:.:.::
Human   762 --KGSALRNPVNLAVLKLNEQGLLDKLKNKWWYD--------KGECGSGGGDSKDKTSALSLSNV 816

  Fly   550 IQIWRFVGWMLGLATIVFLLELICFWRHKMWQNMKYMFC 588
            ..::..:...||||.:|.|:| .|:......:.|| .||
Human   817 AGVFYILIGGLGLAMLVALIE-FCYKSRSESKRMK-GFC 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir94d	NP_001138099.1	None
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..399	CDD:107385	45/304 (15%)
		ANF_receptor	47..382	CDD:279440	44/287 (15%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	68/437 (16%)
		Lig_chan	548..827	CDD:278489	48/333 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156062
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840