DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir94d and Grin3b

DIOPT Version :9

Sequence 1:	NP_001138099.1	Gene:	Ir94d / 7354412	FlyBaseID:	FBgn0259193	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_006513350.1	Gene:	Grin3b / 170483	MGIID:	2150393	Length:	1138	Species:	Mus musculus

Alignment Length:	460	Identity:	81/460 - (17%)
Similarity:	146/460 - (31%)	Gaps:	147/460 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LIHHLNRELKIEYVLLL---GNF----DTTWLDILWQLPVSVLQIKEHSRETYSLLENPSHNVLT 82
            |:..|..:|..::.|.:   |.:    |..|..::.                 .||...:|..:|
Mouse   563 LLERLAEDLAFDFELYIVGDGKYGALRDGRWTGLVG-----------------DLLAGRAHMAVT 610

  Fly    83 IAFVNDSPEDILEILYRNLRMLNTQPVLLVIRKSTIRVNSLLEWCWHHQL-------LKVVAIAQ 140
            ...:|.:...:::.   .....:|...::|..:.|........|..|..:       |.:.|:..
Mouse   611 SFSINSARSQVVDF---TSPFFSTSLGIMVRTRDTASPIGAFMWPLHWSMWVGVFAALHLTALFL 672

  Fly   141 DFMESLIVYSYNPFPVLQFIERRLDNSTVIFEKRLENLHGYEVPIALGGSSPRLIVYRDLEGKLI 205
            ...|....|...|         |..|...:|..                ||...:.|..|.|:.:
Mouse   673 TLYEWRSPYGLTP---------RGRNRGTVFSY----------------SSALNLCYAILFGRTV 712

  Fly   206 FSG----PVGNF------------MKSFEQRYNCRLVQPYPFDE-SAI------SPARDL-IASV 246
            .|.    |.|.|            :.|:.......:|....|:| |.|      .|::.. ..:|
Mouse   713 SSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPSQGFRFGTV 777

  Fly   247 QNGSVQIALGAIYPQV---------PYTGYSYPIELMSWCLMMPVPEEVPHSQLYSMVFSPMAFG 302
            ...|.:..:.|.:|::         |.|.:...:          :..:.|....:.|..|.:.:.
Mouse   778 WESSAEAYIKASFPEMHAHMRRHSAPTTPHGVAM----------LTSDPPKLNAFIMDKSLLDYE 832

  Fly   303 ITIVAMVLISLTLSMALRLHGYRV----------SFSEY-----------FLHDS------CLRG 340
            ::|.|...: ||:.....:.||.:          :.||:           .|||.      |.:.
Mouse   833 VSIDADCKL-LTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKR 896

  Fly   341 VLSQSFYEVLRAPAL-IKAMYLVICL-LG-LLITSWYNSYFSTFVTSAPRFPQLTSYESIRHSNI 402
            |.:.:  |.|:.... :..:::::|| || .|:||.....|...|  .||         ||..|
Mouse   897 VFAVT--ETLQMGVYHLSGLFVLLCLGLGSALLTSLGEHVFYRLV--LPR---------IRRGN- 947

  Fly   403 KIVIW 407
            |:..|
Mouse   948 KLQYW 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir94d	NP_001138099.1	None
Grin3b	XP_006513350.1	PBP1_iGluR_NMDA_NR3	141..481	CDD:380600
		PBP2_iGluR_NMDA_Nr3	494..888	CDD:270438	61/380 (16%)
		Lig_chan	656..922	CDD:365843	50/303 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846669
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930