DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir94d and Grik5

DIOPT Version :9

Sequence 1:	NP_001138099.1	Gene:	Ir94d / 7354412	FlyBaseID:	FBgn0259193	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_030098003.1	Gene:	Grik5 / 14809	MGIID:	95818	Length:	1003	Species:	Mus musculus

Alignment Length:	495	Identity:	91/495 - (18%)
Similarity:	170/495 - (34%)	Gaps:	110/495 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 IERRLDNSTVIFEKRLENLHGYEVPIALGGSSPRLIVYRDLEGKLIFSGPVGNFMKSFEQ----R 220
            :.:.|.|.|::....|||.:....|           .::.|.|...|.|...:.::...:    |
Mouse   431 LSQTLANKTLVVTTILENPYVMRRP-----------NFQALSGNERFEGFCVDMLRELAELLRFR 484

  Fly   221 YNCRLVQ------PYPFDESAISPARDLIASVQNGSVQIALGAIYPQ-VPYTGYSYPIELMSWCL 278
            |..|||:      |.| :.|......:|| :.|...:.:|...|..: .....:|.|...:...:
Mouse   485 YRLRLVEDGLYGAPEP-NGSWTGMVGELI-NRQKADLAVAAFTITAEREKVIDFSKPFMTLGISI 547

  Fly   279 MMPV-PEEVPHSQLYSMVFSPMAFGITIVAMVLISLTLSMALRLHGYRVSFSEYFLHDSCLR--- 339
            :..| ....|....:...|||..:...::|.:.:|..|.:|.||..|     |::....|||
Mouse   548 LYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPY-----EWYNPHPCLRARP 607

  Fly   340 -----------------GVLSQSFYEVLRAPALIKAMYLVICLLG------LLITSWYNSYFSTF 381
                             |...|...|::  |..:...    |:.|      |:|.|.|.:..:.|
Mouse   608 HILENQYTLGNSLWFPVGGFMQQGSEIM--PRALSTR----CVSGVWWAFTLIIISSYTANLAAF 666

  Fly   382 VT-SAPRFPQLTSYESIRHSNIKIVIWKPEYEMLLFFSENMEKYSSIFQLQEDYKEFLHLRDS-- 443
            :| .....|..::.:....:||:.........|..|.:...:.|..::...:..:..:.::.:
Mouse   667 LTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEE 731

  Fly   444 -----FDTRYGYMMPMEKWSLMKEQQRVFSSPLFSLQDDLCVFHTVPIVFPMVKNSIFKEPFDRL 503
                 .::||.:::.    |.|.|..|..:..|..:..   :..|......|...|.|::.....
Mouse   732 GIARVLNSRYAFLLE----STMNEYHRRLNCNLTQIGG---LLDTKGYGIGMPLGSPFRDEITLA 789

  Fly   504 ILDVTATGLLSRWRDMSFTEMIK-----AGQLGLEDRGHPKEFRAMKVGDLIQIWRFVGWMLGLA 563
            ||.:.....|         |::|     .|:...|:....|......:|.:     ||..:.||.
Mouse   790 ILQLQENNRL---------EILKRKWWEGGRCPKEEDHRAKGLGMENIGGI-----FVVLICGLI 840

  Fly   564 TIVFLLELICFWR-------------HKMWQNMKY-MFCR 589
            ..||:..:...|.             .:|.|.::: :.||
Mouse   841 IAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCR 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir94d	NP_001138099.1	None
Grik5	XP_030098003.1	PBP1_iGluR_Kainate_KA1_2	23..424	CDD:380616
Grik5	XP_030098003.1	Periplasmic_Binding_Protein_Type_2	437..808	CDD:419667	75/410 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846681
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840