DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir94d and Grid2

DIOPT Version :9

Sequence 1:	NP_001138099.1	Gene:	Ir94d / 7354412	FlyBaseID:	FBgn0259193	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_032193.1	Gene:	Grid2 / 14804	MGIID:	95813	Length:	1007	Species:	Mus musculus

Alignment Length:	682	Identity:	113/682 - (16%)
Similarity:	206/682 - (30%)	Gaps:	268/682 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 NRELKIEY----VLLLGN-FDTTWLDILWQLPVSVLQIKEHS------RETYSLLENPSHNVLT- 82
            |.|:...|    ||||.| |.....|..|....|:..|:::|      |.....::....|.||
Mouse   319 NMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVNGLTG 383

  Fly    83 -IAFVND--SPEDILEIL---Y-----RNLRMLNTQPVLLVIRKSTIRVNSLLEWCWHHQLLKVV 136
             :.|..:  :|....|||   |     |.:|.|.                     ||
Mouse   384 DLEFGENGGNPNVHFEILGTNYGEELGRGVRKLG---------------------CW-------- 419

  Fly   137 AIAQDFMESLIVYSYNPFPVL--QFIERRLDNSTVIFEKRLENLHGYEVPIALGGSSPRLIVYRD 199
                           ||...|  ...:::|:|          |:.|..:.:......|.::|..:
Mouse   420 ---------------NPVTGLNGSLTDKKLEN----------NMRGVVLRVVTVLEEPFVMVSEN 459

  Fly   200 LEGKLIFSGPVGNFMKSFEQRYNCRLVQPYPFDESAISPARDLIASVQNGSVQIALGAIYPQVPY 264
            :.||                        |..:...:|    |::.::.|               |
Mouse   460 VLGK------------------------PKKYQGFSI----DVLDALSN---------------Y 481

  Fly   265 TGYSY------------PIELMSWCLMMPVPEEVPHSQLYSMVFSPMAFGITIVAMVLISLTLSM 317
            .|::|            |.|..:|           :..:..:||.....||:
Mouse   482 LGFNYEIYVAPDHKYGSPQEDGTW-----------NGLVGELVFKRADIGIS------------- 522

  Fly   318 ALRLHGYR---VSFSEYFLHDSCLRGVLSQSFYEVLRAPALIKAMYL--------VICLLGLLI- 370
            ||.:...|   |.|:..::..|.  |||.:...:.:...|.:....|        .:.|:|||:
Mouse   523 ALTITPDRENVVDFTTRYMDYSV--GVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVY 585

  Fly   371 -----------------TSWYNS---YFSTFVTSAPRFPQLTSYESIRHSNIKIVIWKPEYEMLL 415
                             |:.|||   .:.:||......|    |.::....:....|.....::.
Mouse   586 LLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVP----YTTLATRMMMGAWWLFALIVIS 646

  Fly   416 FFSENMEKYSSIFQLQEDYKEFLHLRDSFDTRYGYMM--------------PMEKWSLMKEQQRV 466
            .::.|:..:.:|.:::...:....|....|..||.::              |.|:.|:..:..|:
Mouse   647 SYTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPFERDSMYSQMWRM 711

  Fly   467 FSS--------------------------------PLFSLQDDLCVFHTVPIV-------FPMVK 492
            .:.                                ...::.|..|.|:||...       ..:..
Mouse   712 INRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQH 776

  Fly   493 NSIFKEPFDRLILDVTATG----LLSRWRDMSFTEMIKAGQLGLEDRGHPKE-FRAMKVGDLIQI 552
            .|.:::.|.:.||::..:|    |..:|       ..|.||..|......|: ..|:.:..|..:
Mouse   777 GSPYRDVFSQRILELQQSGDMDILKHKW-------WPKNGQCDLYSSVDAKQKGGALDIKSLAGV 834

  Fly   553 WRFVGWMLGLATIVFLLELICFWRHKMWQNMK 584
            :..:...:.|:.::.:||.   |    |...|
Mouse   835 FCILAAGIVLSCLIAVLET---W----WSRRK 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir94d	NP_001138099.1	None
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		9/25 (36%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:385651	32/153 (21%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	65/445 (15%)
		Interaction with AP4M1. /evidence=ECO:0000250\|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846509
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840