DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir94d and Grid1

DIOPT Version :9

Sequence 1:	NP_001138099.1	Gene:	Ir94d / 7354412	FlyBaseID:	FBgn0259193	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_032192.2	Gene:	Grid1 / 14803	MGIID:	95812	Length:	1009	Species:	Mus musculus

Alignment Length:	714	Identity:	120/714 - (16%)
Similarity:	233/714 - (32%)	Gaps:	233/714 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ALVLLSP-GGDSFYHSLIH-----------HLNRELKIEYVLLLGNFDTTWLDILWQLPVSVLQI 62
            |::|||| |..||.:..:.           .:|.|:....:|.|.:.....:.::.|:..|....
Mouse   227 AILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDN 291

  Fly    63 KEHSRETY---SLLENPSHNVLTI-----AFVNDSPEDILEILYRNL--RMLNTQPVLLVIRKST 117
            ::..|..:   |||.:|....|.:     .::.||...:....:|.|  |..::...|..|||||
Mouse   292 QKCMRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKST 356

  Fly   118 IRVN---SLLEWCWHHQLLKVVAIAQDFMESLIVYSYNPFPVLQFIERRLDNSTVIFEKRLENLH 179
            ...|   |:|:......:..:..: .:|.|.    |.||:...:.:......:   |.|.:..|.
Mouse   357 KPWNGGRSMLDTIKKGHITGLTGV-MEFRED----SSNPYVQFEILGTTYSET---FGKDMRKLA 413

  Fly   180 GYEVPIALGGSSPRLIVYRDLEGKLIFSGPVGNFMKSFEQRYNCRLVQPYPFDESAISPARDLIA 244
            .::....|.||              :...|:|:.::....:....|.:|:      :..|.:::.
Mouse   414 TWDSEKGLNGS--------------LQERPMGSRLQGLTLKVVTVLEEPF------VMVAENILG 458

  Fly   245 S---VQNGSVQI------ALGAIYP--QVPYTGYSYPIELMSW---------------------- 276
            .   .:..|:.:      |||..|.  |.|...|.:.:...||
Mouse   459 QPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITIT 523

  Fly   277 ------------------CLMMPVPEEVPHSQLYSMVFSPMAF--------GITIVAMVLISLTL 315
                              .:::..|||  ...::|: |:|..|        .|.:|.:::..|..
Mouse   524 PERESVVDFSKRYMDYSVGILIKKPEE--KISIFSL-FAPFDFAVWACIAAAIPVVGVLIFVLNR 585

  Fly   316 SMALRLHGYRVSFSEYFLHDSCLRGVLSQSFYEVLRAPALIKAMYLVICLLGLLITSWYNSYFST 380
            ..|:|                      |||..:  ..|:....::..|.::           :..
Mouse   586 IQAVR----------------------SQSATQ--PRPSASATLHSAIWIV-----------YGA 615

  Fly   381 FVTSAPRFPQLTSYESIRHSNIKIVI---WKPEYEMLLFFSENMEKYSSIFQLQEDYKEFLHLRD 442
            ||       |.....|:....::||:   |.....:...::.|:..:.::.::....:.|..|..
Mouse   616 FV-------QQGGESSVNSVAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSK 673

  Fly   443 SFDTRYGYMM--------------PMEKWSLMKEQQRVFSS------------------------ 469
            ..:..||.:.              |:|:.|...|..|..|.
Mouse   674 QLEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSNPSEGIRKAKKGNYA 738

  Fly   470 --------PLFSLQDDLCVFHTVPIV----------FPMVKNSIFKEPFDRLILDVTATG----L 512
                    ...:|.||.|   :|.::          ..:...|.:::.|.:.||::..||    |
Mouse   739 FLWDVAVVEYAALTDDDC---SVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVL 800

  Fly   513 LSRWRDMSFTEMIKAGQLGLEDRGHPK-EFRAMKVGDLIQIWRFVGWMLGLATIVFLLELICFW 575
            ..:|       ....|:..|......: |.:::|:.....::..:...|.||.:|..|||  :|
Mouse   801 KQKW-------WPHTGRCDLTSHSSTQTEGKSLKLHSFAGVFCILAIGLLLACLVAALEL--WW 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir94d	NP_001138099.1	None
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269\|PubMed:27418511	21..436		47/230 (20%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	43/203 (21%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	61/430 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846310
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840