DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir94d and Gria2

DIOPT Version :9

Sequence 1:	NP_001138099.1	Gene:	Ir94d / 7354412	FlyBaseID:	FBgn0259193	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001344853.2	Gene:	Gria2 / 14800	MGIID:	95809	Length:	901	Species:	Mus musculus

Alignment Length:	749	Identity:	138/749 - (18%)
Similarity:	236/749 - (31%)	Gaps:	256/749 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DSFYHSLIHHLNRELKIE----------------------------YVLLLGNFDTTWLDIL--- 52
            |..|.||...|  |||.|                            |..::.|...|..|:|
Mouse   189 DETYRSLFQDL--ELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQ 251

  Fly    53 -WQLPVSVLQIKEHSR-------ETYSLLEN---PSHNVLTIAFVNDSPEDILEILYRNLRMLNT 106
             ....||..||.::..       |.:|.||.   |..:..||.:.:....|.::::....|.|..
Mouse   252 FGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRK 316

  Fly   107 QPVLLVIRKST--IRVNSLLEWCWHHQLLKVVAIAQDFMESL------------IVYSYNPFPVL 157
            |.:.:..|.:.  ...|..:.|....::.:  |:.|..:|.|            |.|:.|...:.
Mouse   317 QRIEISRRGNAGDCLANPAVPWGQGVEIER--ALKQVQVEGLSGNIKFDQNGKRINYTINIMELK 379

  Fly   158 QFIERR-------------------------LDNSTVIFEKRLENLHGYEVPIALGGSSPRLIVY 197
            ....|:                         |:|.||:....||              ||.:::.
Mouse   380 TNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILE--------------SPYVMMK 430

  Fly   198 RD---LEGKLIFSG----PVGNFMKSFEQRYNCRLVQPYPFDESAISPARDLIASVQNGSV-QIA 254
            ::   |||...:.|    ......|....:|...:|....:.      |||....:.||.| ::.
Mouse   431 KNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYG------ARDADTKIWNGMVGELV 489

  Fly   255 LG----AIYP------QVPYTGYSYPIELMSWCLMMPVPEEVPHSQLYSMVFS---PMAFGI--- 303
            .|    ||.|      :.....:|.|...:...:|:..|::....     |||   |:|:.|
Mouse   490 YGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPG-----VFSFLDPLAYEIWMC 549

  Fly   304 TIVAMVLISLTLSMALRLHGYR---------------VSFSEYFLHDSC--LRGVLSQSFYEVLR 351
            .:.|.:.:|:.|.:..|...|.               .|.:|:.:.:|.  ..|...|...::
Mouse   550 IVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDI-- 612

  Fly   352 APALIKAMYL--VICLLGLLITSWYNSYFSTFVTSAPRFPQLTSYESI----------------- 397
            :|..:....:  |.....|:|.|.|.:..:.|:|.......:.|.|.:
Mouse   613 SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTK 677

  Fly   398 ---RHSNI----KIVIWKPEYEMLLFFSENME----------KYSSIFQLQEDYKEFLHLRDSFD 445
               |.|.|    |:..:....|..:|.....|          ||:  :.|:....|::..|...|
Mouse   678 EFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYA--YLLESTMNEYIEQRKPCD 740

  Fly   446 TR----------YGYMMPMEKWSLMKEQQRVFSSPLFSLQDDLCVFHTVPIVFPMVKNSIFKEPF 500
            |.          ||...|                                      |.|..:.|.
Mouse   741 TMKVGGNLDSKGYGIATP--------------------------------------KGSSLRTPV 767

  Fly   501 DRLILDVTATGLLSR-----WRDMSFTEMIKAGQLGLEDRGHPKEFRAMKVGDLIQIWRFVGWML 560
            :..:|.::..|:|.:     |.|        .|:.|.:|.|..::..|:.:.::..::..:...|
Mouse   768 NLAVLKLSEQGVLDKLKNKWWYD--------KGECGAKDSGSKEKTSALSLSNVAGVFYILVGGL 824

  Fly   561 GLATIVFLLELICFWRHKMWQNMKYMF---CRNK 591
            |||.:|.|:| .|:......:.||...   .|||
Mouse   825 GLAMLVALIE-FCYKSRAEAKRMKMTLSAATRNK 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir94d	NP_001138099.1	None
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	40/212 (19%)
Gria2	NP_001344853.2	PBP2_iGluR_AMPA	413..794	CDD:270433	80/455 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846679
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930