DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42391 and TNKS2

DIOPT Version :9

Sequence 1:	NP_001137671.1	Gene:	CG42391 / 7354405	FlyBaseID:	FBgn0259737	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	XP_005270242.2	Gene:	TNKS2 / 80351	HGNCID:	15677	Length:	1190	Species:	Homo sapiens

Alignment Length:	187	Identity:	38/187 - (20%)
Similarity:	70/187 - (37%)	Gaps:	43/187 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 NISNLIKFVRQHSKWYRDND----------CINRHYFNYILLDPRVTNNLKERASQLHLMDVW-Y 113
            |..::::::.||.......|          |...||        .|...|.:..:.:::.|:| :
Human   561 NRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHY--------EVAELLVKHGAVVNVADLWKF 617

  Fly   114 TFLRAIFYVGKGKATRPYVHLKN----AQKLVDETNNITLVKD----------PKLALIVSIWKA 164
            |.|...  ..|||.....:.|::    .:|..|....:.||||          ...||:.:   |
Human   618 TPLHEA--AAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDA---A 677

  Fly   165 NRGVLL----IRAFQGISSQDAQTREASIID-ALGMNHLTNRRLGFYYGRARSLSDK 216
            .:|.|.    :.:...::.:|.|.|.::.:. |.|.|:|........:|...:..||
Human   678 KKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDK 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42391	NP_001137671.1	Peptidase_S80	<37..>101	CDD:305105	9/50 (18%)
CG42391	NP_001137671.1	GIY-YIG_COG3680_Meta	85..200	CDD:198401	29/134 (22%)
TNKS2	XP_005270242.2	Ank_2	28..142	CDD:372319
		ANK repeat	60..109	CDD:293786
		PHA02876	<94..>479	CDD:165207
		ANK repeat	111..142	CDD:293786
		ANK repeat	144..175	CDD:293786
		ANK repeat	234..262	CDD:293786
		ANK repeat	264..295	CDD:293786
		ANK repeat	297..328	CDD:293786
		ANK repeat	386..418	CDD:293786
		ANK repeat	420..451	CDD:293786
		ANK repeat	453..482	CDD:293786
		PHA03095	540..>826	CDD:222980	38/187 (20%)
		ANK repeat	552..580	CDD:293786	3/18 (17%)
		ANK repeat	582..613	CDD:293786	5/38 (13%)
		ANK repeat	615..646	CDD:293786	7/32 (22%)
		ANK repeat	668..698	CDD:293786	5/32 (16%)
		ANK repeat	705..733	CDD:293786	5/27 (19%)
		ANK repeat	735..766	CDD:293786	38/187 (20%)
		ANK repeat	768..799	CDD:293786
		SAM_tankyrase1,2	895..960	CDD:188923
		tankyrase_like	962..1184	CDD:238718
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900