DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42391 and PIDD1

DIOPT Version :9

Sequence 1:	NP_001137671.1	Gene:	CG42391 / 7354405	FlyBaseID:	FBgn0259737	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	XP_005253062.1	Gene:	PIDD1 / 55367	HGNCID:	16491	Length:	934	Species:	Homo sapiens

Alignment Length:	200	Identity:	43/200 - (21%)
Similarity:	63/200 - (31%)	Gaps:	66/200 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 WYRDNDCI-----------NRHYFNYILL----DPR--------------VTNNLKERASQLHLM 109
            ||...:|:           ..|..|.|.|    ||.              ....|.||.......
Human   617 WYTTKNCVGGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLRRLLERYRGPEPS 681

  Fly   110 DVWYTFLRAIFYVG--KG---KATRP-----------YVHLKNAQKLVDETNNITLVKDPKLALI 158
            |....|....|:..  :|   .|.||           |.||||.:::.     :|...|.:...:
Human   682 DTVEMFEGEEFFAAFERGIDVDADRPDCVEGRICFVFYSHLKNVKEVY-----VTTTLDREAQAV 741

  Fly   159 ---VSIWKANRGVLLIRAFQGISSQDAQTREASIIDALGMNHLTNRRLGFYYGRARSLSDKERKY 220
               ||.:   ||.:.:|    :..:....|:....|||.|     ..|.....|.|. |:..|:.
Human   742 RGQVSFY---RGAVPVR----VPEEAEAARQRKGADALWM-----ATLPIKLPRLRG-SEGPRRG 793

  Fly   221 LGIAL 225
            .|::|
Human   794 AGLSL 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42391	NP_001137671.1	Peptidase_S80	<37..>101	CDD:305105	10/55 (18%)
CG42391	NP_001137671.1	GIY-YIG_COG3680_Meta	85..200	CDD:198401	32/151 (21%)
PIDD1	XP_005253062.1	leucine-rich repeat	39..63	CDD:275380
		leucine-rich repeat	64..91	CDD:275380
		LRR_RI	<117..>279	CDD:238064
		LRR_8	126..183	CDD:290566
		leucine-rich repeat	127..152	CDD:275380
		leucine-rich repeat	153..172	CDD:275380
		leucine-rich repeat	173..195	CDD:275380
		LRR_8	194..252	CDD:290566
		leucine-rich repeat	196..218	CDD:275380
		leucine-rich repeat	219..241	CDD:275380
		LRR_8	240..295	CDD:290566
		leucine-rich repeat	242..264	CDD:275380
		leucine-rich repeat	265..286	CDD:275380
		ZU5	325..398	CDD:295340
		Peptidase_S68	421..453	CDD:287439
		ZU5	465..537	CDD:295340
		Death_PIDD	812..897	CDD:260049
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900