DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42391 and ANKRD62

DIOPT Version :9

Sequence 1:	NP_001137671.1	Gene:	CG42391 / 7354405	FlyBaseID:	FBgn0259737	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_001264262.1	Gene:	ANKRD62 / 342850	HGNCID:	35241	Length:	917	Species:	Homo sapiens

Alignment Length:	264	Identity:	53/264 - (20%)
Similarity:	101/264 - (38%)	Gaps:	46/264 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 KSKVKARPISYSLGTLHKH-HTNFST-ELENTINSESNF--KNISNL------IKFVRQ--HSKW 74
            :||:..:.:...|.|:..: :.||.| |.|..:..|::.  ..|:.|      ||...|  .:|:
Human   525 QSKLTLKSLEVELKTVRSNSNQNFHTHERERDLWQENHLMRDEIARLRLEIDTIKHQNQETENKY 589

  Fly    75 YRDNDCI--NRHYFNYILL--DPRVTNNLKERASQLHLMDVWYTFLRAIFYVGKGKATRPYVHLK 135
            ::|.:.|  |.......|.  :..:|..:...:.:|:::....|.|.:.....|...:|....::
Human   590 FKDIEIIKENNEDLEKTLKRNEEALTKTITRYSKELNVLMDENTMLNSELQKEKQSMSRLETEME 654

  Fly   136 N-----AQKLVDETNNITLVKDPKLAL--IVSIW-----KANRGVLLI--------RAFQGISSQ 180
            :     |..|.|.....:..:|.:||.  .|:.|     ..|..:.::        ....|:.::
Human   655 SYRCRLAAALCDHDQRQSSKRDLQLAFQSTVNEWCHLQEDTNSHIQILSQQLSKAESTSSGLETE 719

  Fly   181 DAQTREASIIDALGMNHLTNRRLGFYYGRARSLSDKERKYLGIALLYKLMMKFLAKE---EKELF 242
            ....|||.....|.:.|:.    |......|.|.|.|..|...   ..::.|::.|:   |..||
Human   720 LHYEREALKEKTLHIEHMQ----GVLSRTQRRLEDIEHMYQND---QPILEKYVRKQQSVEDGLF 777

  Fly   243 PLKN 246
            .|::
Human   778 QLQS 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42391	NP_001137671.1	Peptidase_S80	<37..>101	CDD:305105	17/79 (22%)
CG42391	NP_001137671.1	GIY-YIG_COG3680_Meta	85..200	CDD:198401	22/136 (16%)
ANKRD62	NP_001264262.1	Ank_4	42..92	CDD:290365
		ANK repeat	42..69	CDD:293786
		ANK	66..191	CDD:238125
		ANK 1	71..100
		ANK repeat	73..102	CDD:293786
		Ank_2	76..167	CDD:289560
		ANK repeat	104..135	CDD:293786
		ANK 2	104..133
		ANK	132..256	CDD:238125
		ANK repeat	137..167	CDD:293786
		ANK 3	137..166
		Ank_2	142..234	CDD:289560
		ANK repeat	170..201	CDD:293786
		ANK 4	170..199
		ANK repeat	203..234	CDD:293786
		ANK 5	203..232
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	265..367
		CCDC144C	561..846	CDD:291576	43/228 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152082
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930