DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42391 and ANKRD18A

DIOPT Version :9

Sequence 1:	NP_001137671.1	Gene:	CG42391 / 7354405	FlyBaseID:	FBgn0259737	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	XP_024303251.1	Gene:	ANKRD18A / 253650	HGNCID:	23643	Length:	1170	Species:	Homo sapiens

Alignment Length:	258	Identity:	44/258 - (17%)
Similarity:	93/258 - (36%)	Gaps:	61/258 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PISYSLGTLHKHHTNFSTELENTINSESNFK----------NISNLIKFVRQHSKWYRDNDCINR 83
            |:.:::.:..:|...|..:.:..|::..|||          |:|:::..:.|.:......|...:
Human   170 PLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQ 234

  Fly    84 HYFNYILLDPRVTNNLKERASQL--HLMDVWYTFLRAIFYVGKGKATRPYVHLKNAQKLVDETNN 146
            ...:|.|     .::|:....|:  |                |.|..:.::...|.:....:..|
Human   235 TAEDYAL-----CSDLRSIRQQILEH----------------KNKMLKNHLRNDNQETAAMKPAN 278

  Fly   147 ITLVKDPKLA----LIVSIWKANRGVLLIRAFQGISSQDAQTREASIIDALGMNHLTNRRLGF-- 205
            :...|:...|    .:.|..|..|    ::..:....||:|: .....||:..|.:..:.:..
Human   279 LKKRKERAKAEHNLKVASEEKQER----LQRSENKQPQDSQS-YGKKKDAMYGNFMLKKDIAMLK 338

  Fly   206 --YYGRARSLSDKERKYL---------------GIALLYKLMMKFLAKEEKELFPLKNTKAAM 251
              .|........||:||:               .:.|..|::.|.:|:..::|..||...|.:
Human   339 EELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARL 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42391	NP_001137671.1	Peptidase_S80	<37..>101	CDD:305105	13/73 (18%)
CG42391	NP_001137671.1	GIY-YIG_COG3680_Meta	85..200	CDD:198401	20/120 (17%)
ANKRD18A	XP_024303251.1	Ank_4	34..88	CDD:316185
		ANK repeat	38..65	CDD:293786
		ANK	62..187	CDD:238125	3/16 (19%)
		ANK repeat	69..98	CDD:293786
		ANK repeat	100..131	CDD:293786
		ANK	128..253	CDD:238125	15/87 (17%)
		ANK repeat	133..164	CDD:293786
		ANK repeat	166..197	CDD:293786	4/26 (15%)
		ANK repeat	199..230	CDD:293786	5/30 (17%)
		CCDC144C	327..617	CDD:317340	14/75 (19%)
		SMC_N	<460..907	CDD:330553
		DUF3496	865..969	CDD:314818
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152066
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930