DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42391 and Ankle1

DIOPT Version :9

Sequence 1:	NP_001137671.1	Gene:	CG42391 / 7354405	FlyBaseID:	FBgn0259737	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_766344.2	Gene:	Ankle1 / 234396	MGIID:	1918775	Length:	534	Species:	Mus musculus

Alignment Length:	171	Identity:	70/171 - (40%)
Similarity:	99/171 - (57%)	Gaps:	6/171 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 KWYRDNDCINRHYFNYILLDPRVTNNLKERASQLHLMDVWYTFLRAIFYVGKGKATRPYVHLKNA 137
            ||   .:.|.:..|.|:|||||:|.:|..|||.|.|.:....|:|||||||||...||..||..|
Mouse   363 KW---REGITKSSFTYLLLDPRLTKDLPARASSLTLAECLQCFVRAIFYVGKGTRARPDAHLWEA 424

  Fly   138 QKLVDETNNITLVKDPKLALIVSIWKANRGVLLIRAFQGISSQDAQTREASIIDALGMNHLTNRR 202
            ....|:......   ||:..|:.||.:.||::.:..||.:.:.:|.||||.::||||:..|||::
Mouse   425 FGYHDQPRKQVC---PKVRRILDIWASGRGIISLHCFQHVVAMEAYTREACLLDALGLQTLTNQK 486

  Fly   203 LGFYYGRARSLSDKERKYLGIALLYKLMMKFLAKEEKELFP 243
            .|.|||.........|:.||:.||.:.::.|||:.|:||.|
Mouse   487 QGHYYGVVAHWPPSRRRRLGVHLLQRALLVFLAEGERELRP 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42391	NP_001137671.1	Peptidase_S80	<37..>101	CDD:305105	12/27 (44%)
CG42391	NP_001137671.1	GIY-YIG_COG3680_Meta	85..200	CDD:198401	49/114 (43%)
Ankle1	NP_766344.2	ANK 1. /evidence=ECO:0000255	4..35
		ANK	26..128	CDD:238125
		Ank_2	26..106	CDD:289560
		ANK 2. /evidence=ECO:0000255	39..71
		ANK repeat	75..106	CDD:293786
		ANK 3. /evidence=ECO:0000255	75..104
		Ank_4	76..128	CDD:290365
		ANK 4. /evidence=ECO:0000255	108..137
		LEM	285..322	CDD:295412
		GIY-YIG_COG3680_Meta	372..484	CDD:198401	49/114 (43%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q8NAG6	498..505		1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3306
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840