DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42391 and Ank2

DIOPT Version :9

Sequence 1:	NP_001137671.1	Gene:	CG42391 / 7354405	FlyBaseID:	FBgn0259737	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	XP_036018747.1	Gene:	Ank2 / 109676	MGIID:	88025	Length:	4152	Species:	Mus musculus

Alignment Length:	242	Identity:	51/242 - (21%)
Similarity:	76/242 - (31%)	Gaps:	90/242 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QTIPLQLRNNFKSKVKARPISYSLGTLHKHHTNFSTE-----LENTINSESNFKNISNLIK---F 67
            |.:.:.|.|:.|.||:       |..||.......|:     |:|..|::...|.:.|...   |
Mouse   194 QAVAILLENDTKGKVR-------LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF 251

  Fly    68 VRQHSKWYRDNDCINRHYFNYILLDPRVTNNLKERASQLHLMDVWYTFLRAIFYVGKGKATRPYV 132
            ...|         |..||.|.     .|...|..|.:             |:.:..:...|..:|
Mouse   252 TPLH---------IAAHYGNV-----NVATLLLNRGA-------------AVDFTARNGITPLHV 289

  Fly   133 HLKNAQKLVDETNNITLVKDPKLALIVSIWKANRGVLLIRAFQGISSQDAQTREASIIDALGMNH 197
            ..|..     .||.:.|:.|             ||          ...||:||:       |:..
Mouse   290 ASKRG-----NTNMVKLLLD-------------RG----------GQIDAKTRD-------GLTP 319

  Fly   198 LTNRRLGFYYGRARSLSDKERKYLGIALLYKLMMKFLAKEEKELFPL 244
            |        :..|||..|:.     :.||.:.....||:.:..|.||
Mouse   320 L--------HCAARSGHDQV-----VELLLERKAPLLARTKNGLSPL 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42391	NP_001137671.1	Peptidase_S80	<37..>101	CDD:305105	16/71 (23%)
CG42391	NP_001137671.1	GIY-YIG_COG3680_Meta	85..200	CDD:198401	21/114 (18%)
Ank2	XP_036018747.1	PHA03095	46..>354	CDD:222980	51/242 (21%)
		ANK repeat	80..111	CDD:293786
		ANK repeat	113..144	CDD:293786
		ANK repeat	146..171	CDD:293786
		Ank_2	202..>444	CDD:423045	49/234 (21%)
		ANK repeat	212..247	CDD:293786	8/34 (24%)
		ANK repeat	249..280	CDD:293786	10/57 (18%)
		ANK repeat	282..313	CDD:293786	11/58 (19%)
		ANK repeat	315..345	CDD:293786	9/49 (18%)
		ANK repeat	348..379	CDD:293786	3/6 (50%)
		ANK repeat	381..411	CDD:293786
		ANK repeat	414..445	CDD:293786
		PHA03095	421..>706	CDD:222980
		ANK repeat	447..478	CDD:293786
		ANK repeat	480..511	CDD:293786
		ANK repeat	513..542	CDD:293786
		ANK repeat	546..571	CDD:293786
		Ank_2	578..>802	CDD:423045
		ANK repeat	579..604	CDD:293786
		ANK repeat	612..643	CDD:293786
		ANK repeat	645..676	CDD:293786
		ANK repeat	678..707	CDD:293786
		ANK repeat	711..742	CDD:293786
		ANK repeat	744..775	CDD:293786
		ANK repeat	777..806	CDD:293786
		Ank_4	778..830	CDD:372654
		ZU5	1013..1150	CDD:128514
		UPA_2	1371..1500	CDD:375346
		PHA03307	1823..>2031	CDD:223039
		PTZ00449	<2261..2668	CDD:185628
		COG5665	<2758..>2989	CDD:227952
		PHA03307	3210..>3537	CDD:223039
		Death_ank2	3595..3678	CDD:260066
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900