DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17454 and Smn1

DIOPT Version :9

Sequence 1:	NP_001138001.1	Gene:	CG17454 / 7354399	FlyBaseID:	FBgn0039977	Length:	243	Species:	Drosophila melanogaster
Sequence 2:	NP_071954.2	Gene:	Smn1 / 64301	RGDID:	620755	Length:	288	Species:	Rattus norvegicus

Alignment Length:	107	Identity:	31/107 - (28%)
Similarity:	48/107 - (44%)	Gaps:	9/107 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 KIWKKGDKCQAKWKEDRQYYDATIEDISSTGEV-NVIFDAYQNRSTTHVNELRERTIRNEVFPSN 153
            |.||.||||.|.|.||...|.|||..:....|. .|::..|.|:...::::|...|.  ||  :|
  Rat    87 KQWKAGDKCSAVWSEDGCVYPATITSVDLKRETCVVVYTGYGNKEEQNLSDLLSPTC--EV--AN 147

  Fly   154 KRHRPNQKEYLKKRKQKKQQRFKDLEEERESDKNK---WLNF 192
            ...:..|:...:......:...:.|..:..| |:|   |.:|
  Rat   148 NTEQNTQENESQVSTDDSEHSSRSLRSKAHS-KSKAAPWTSF 188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17454	NP_001138001.1	TroA-like	<22..>116	CDD:294188	15/25 (60%)
CG17454	NP_001138001.1	TUDOR	95..142	CDD:119391	17/47 (36%)
Smn1	NP_071954.2	P1 (binding site for GEMIN2). /evidence=ECO:0000250	10..41
		SMN	24..280	CDD:399180	31/107 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	54..87		31/107 (29%)
		Required for interaction with RPP20/POP7. /evidence=ECO:0000250	94..204		26/100 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..225		7/41 (17%)
		P2 (binding site for SM B). /evidence=ECO:0000250	234..261
		Required for interaction with SYNCRIP. /evidence=ECO:0000250	273..288
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539238at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010