DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lectin-22C and CLEC4A

DIOPT Version :9

Sequence 1:	NP_001137766.1	Gene:	lectin-22C / 7354375	FlyBaseID:	FBgn0259230	Length:	263	Species:	Drosophila melanogaster
Sequence 2:	NP_057268.1	Gene:	CLEC4A / 50856	HGNCID:	13257	Length:	237	Species:	Homo sapiens

Alignment Length:	130	Identity:	32/130 - (24%)
Similarity:	55/130 - (42%)	Gaps:	21/130 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 FEQIGSKYYYIEKVSEKNWSTASKTCRNMGGHLADIKDEADLAAIKANLKEDTHYWLGINDLDHE 203
            ::...|..|:|...| .:|..:.|.|..|..||..|..:.:...|..||:|::.|::|::|.:.:
Human   110 WKSFSSNCYFISTES-ASWQDSEKDCARMEAHLLVINTQEEQDFIFQNLQEESAYFVGLSDPEGQ 173

  Fly   204 GKFL---SMPTGKQTTFLKWASGRPSQLDTLNCVFL----------YNGEMYDYPCHYTFRFICQ 255
            ..:.   ..|..:.:||  |....||..:. .||.|          :|    |..|....|.:|:
Human   174 RHWQWVDQTPYNESSTF--WHPREPSDPNE-RCVVLNFRKSPKRWGWN----DVNCLGPQRSVCE 231

Fly 256 255
Human 232 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lectin-22C	NP_001137766.1	CLECT	146..255	CDD:153057	30/121 (25%)
CLEC4A	NP_057268.1	ITIM motif. /evidence=ECO:0000269\|PubMed:20530286	5..10
		CLECT_DC-SIGN_like	106..232	CDD:153060	32/130 (25%)
		Mannose binding. /evidence=ECO:0000269\|PubMed:27015765, ECO:0007744\|PDB:5B1X	195..197		0/1 (0%)
		N-acetyl-D-glucosamine binding. /evidence=ECO:0000269\|PubMed:27015765, ECO:0007744\|PDB:5B1X	207..209		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010