DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lectin-22C and Clec4a

DIOPT Version :9

Sequence 1:	NP_001137766.1	Gene:	lectin-22C / 7354375	FlyBaseID:	FBgn0259230	Length:	263	Species:	Drosophila melanogaster
Sequence 2:	NP_001005899.2	Gene:	Clec4a / 474143	RGDID:	1359662	Length:	240	Species:	Rattus norvegicus

Alignment Length:	167	Identity:	47/167 - (28%)
Similarity:	75/167 - (44%)	Gaps:	30/167 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 ERLNCMEGILSALEKTVLEVKTKIKYLGFEQIGSKYYYIEK----VSEKNWSTASKTCRNMGGHL 171
            :.|||::.:|...||:     .......::..||..|::.|    .|:.:|:.:.|.|.:||.||
  Rat    88 KELNCIKNVLLMEEKS-----WSCCPKNWKPFGSHCYWVTKHTSTYSKASWNESEKNCFSMGAHL 147

  Fly   172 ADI--KDEADLAAIKANLKEDTHYWLGINDLDH-EGKFLSM-PTGKQTTFLKWASGRPSQLDTLN 232
            ..|  |:|.|.  |...|..|..|::|:.|..| :.:::|. |.....||  |..|.||. |...
  Rat   148 LVIHSKEEQDF--ITGILNRDAAYFIGLWDSGHRQWQWVSQTPYNASATF--WHKGEPSS-DDEK 207

  Fly   233 CVFL--------YNGEMYDYPCHYTFRFICQTEEEDL 261
            ||.:        :|    |.||....:.:||.::..|
  Rat   208 CVIINHLNSGWGWN----DIPCSGKQQSVCQMKKIQL 240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lectin-22C	NP_001137766.1	CLECT	146..255	CDD:153057	36/124 (29%)
Clec4a	NP_001005899.2	ITIM motif	5..10
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..38
		CLECT_DC-SIGN_like	107..235	CDD:153060	39/136 (29%)
		Mannose binding. /evidence=ECO:0000250\|UniProtKB:Q9UMR7	200..202		0/1 (0%)
		N-acetyl-D-glucosamine binding. /evidence=ECO:0000250\|UniProtKB:Q9UMR7	211..213		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010