Protein Alignment UCP3 and Dic1

DIOPT Version :10

• Sequence 1: NP_003347.1
• Gene: UCP3 / 7352
• HGNCID: 12519
• Length: 312
• Species: Homo sapiens
• Sequence 2: NP_650279.1
• Gene: Dic1 / 41640
• FlyBaseID: FBgn0027610
• Length: 280
• Species: Drosophila melanogaster
• Alignment Length: 282
• Identity: 93/282 - (32%)
• Similarity: 145/282 - (51%)
• Gaps: 19/282 - (6%)

Human    17 FLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGL 81
            |.| |.|:..|.:||.|||..||.||.|..:.:|  |:|:.         .:.|.:|....||||
  Fly    11 FFG-GLASVGAAMVTHPLDLIKVTLQTQQGHLSV--AQLIP---------KLAREQGVLVFYNGL 63

Human    82 VAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQA 146
            .|.:.||:::::.|.|:|::.|     |..:..|...::.....:|.:......|.|:|.||.|.
  Fly    64 SASVLRQLTYSTARFGVYEAGK-----KYVNTDSFGGKVALAGASGLVGGIVGTPADMVNVRMQN 123

Human   147 SIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYH 211
            .:.| |.:..|.|:...|....:.|:||.:.|:.|......|..::...::..||..|..||...
  Fly   124 DVKL-PPQQRRNYNNAFDGLVRVYRQEGFKRLFSGATAATARGILMTIGQIAFYDQTKIYLLATP 187

Human   212 LLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGF 276
            ...||...||.::..||..||.:..|:||:|||.||:.||: |:.|..::|..|:.||..|:||:
  Fly   188 YFQDNLVTHFTASLVAGTIATTLTQPLDVLKTRSMNAKPGE-FNGLWDIVKHTAKLGPLGFFKGY 251

Human   277 TPSFLRLGSWNVVMFVTYEQLK 298
            .|:|:|||...::.||..|||:
  Fly   252 VPAFVRLGPHTIITFVFLEQLR 273

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UCP3	NP_003347.1	Mito_carr	10..110	CDD:395101	31/92 (34%)
		Solcar 1	11..105		31/87 (36%)
		Mito_carr	112..210	CDD:395101	24/97 (25%)
		Solcar 2	114..206		22/91 (24%)
		Mito_carr	214..303	CDD:395101	37/85 (44%)
		Solcar 3	215..300		37/84 (44%)
		Purine nucleotide binding. /evidence=ECO:0000250	279..301		9/20 (45%)
Dic1	NP_650279.1	Mito_carr	10..92	CDD:395101	32/97 (33%)
		Mito_carr	89..184	CDD:395101	22/95 (23%)
		Mito_carr	189..278	CDD:395101	37/86 (43%)