DRSC/TRiP Functional Genomics Resources

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Protein Alignment UCP3 and Ucp4B

DIOPT Version :9

Sequence 1:NP_003347.1 Gene:UCP3 / 7352 HGNCID:12519 Length:312 Species:Homo sapiens
Sequence 2:NP_608977.1 Gene:Ucp4B / 33833 FlyBaseID:FBgn0031758 Length:337 Species:Drosophila melanogaster


Alignment Length:306 Identity:108/306 - (35%)
Similarity:161/306 - (52%) Gaps:26/306 - (8%)


- Green bases have known domain annotations that are detailed below.


Human    10 PPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGP 74
            ||...  :|.|..:||.|::|.:|.|..|.|:||||| .|.:..:..:|||:|.|.:.:||.||.
  Fly    35 PPVEL--YLTAFASACSAEIVGYPFDMCKTRMQIQGE-IASRVGQKAKYRGLLATAMGIVREEGL 96

Human    75 CSPYNGLVAGLQRQMSFASIRIGLYDSVKQ---VYTPKGADNSSLTTRILAGCTTGAMAVTCAQP 136
            ...|.|:.|.|.|...|:.|::..||.:::   |....|....|.....::|...||.|.....|
  Fly    97 LKLYGGISAMLFRHSLFSGIKMLTYDYMREKMIVPDEDGRPQLSFLGSCISGVLAGATASVLTNP 161

Human   137 TDVVKVRFQASIHLGPSRSDRKYSG-------TMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNC 194
            |:::|::.|       ....|:..|       .:.|..:|.|..||.||||||:||..|:|:|..
  Fly   162 TELIKIQMQ-------MEGQRRLRGEPPRIHNVLQALTSIYRTGGVVGLWKGTVPNTWRSALVTI 219

Human   195 AEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPPGQ------Y 253
            .:|..||..|..|:....|.||....||:|..||....:::.|.||||:|.||.|..:      |
  Fly   220 GDVSCYDFCKRFLIAEFDLVDNREVQFVAAMTAGVADAILSLPADVVKSRIMNQPTDEQGRGIHY 284

Human   254 FSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKR 299
            ...|||:.::|.:||..|.||||.|.::|:|..:||.::|:||::|
  Fly   285 KGSLDCLSRLVREEGFLAMYKGFIPYWMRVGPASVVFWMTFEQIRR 330

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UCP3NP_003347.1 Mito_carr 10..110 CDD:278578 37/102 (36%)
Solcar 1 11..105 35/96 (36%)
PTZ00169 14..302 CDD:240302 106/302 (35%)
Mito_carr 112..210 CDD:278578 32/104 (31%)
Solcar 2 114..206 31/98 (32%)
Mito_carr 214..303 CDD:278578 37/92 (40%)
Solcar 3 215..300 37/91 (41%)
Purine nucleotide binding. /evidence=ECO:0000250 279..301 8/21 (38%)
Ucp4BNP_608977.1 PTZ00169 32..306 CDD:240302 96/280 (34%)
Mito_carr 32..129 CDD:278578 36/96 (38%)
Mito_carr 138..233 CDD:278578 31/101 (31%)
Mito_carr 246..331 CDD:278578 35/85 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0759
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54059
OrthoDB 1 1.010 - - D382447at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.830

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