Protein Alignment UCP2 and CG7943

DIOPT Version :10

• Sequence 1: NP_003346.2
• Gene: UCP2 / 7351
• HGNCID: 12518
• Length: 309
• Species: Homo sapiens
• Sequence 2: NP_651766.1
• Gene: CG7943 / 43574
• FlyBaseID: FBgn0039741
• Length: 332
• Species: Drosophila melanogaster
• Alignment Length: 336
• Identity: 75/336 - (22%)
• Similarity: 133/336 - (39%)
• Gaps: 67/336 - (19%)

Human     5 KATDVPP-------------------------TATVKFLGA--------GTAACIADL-ITFPLD 35
            |.||.||                         ..:.:|.|:        |..|...:: :|:|:.
  Fly    11 KTTDPPPPKRFPSGRAHSPHGDGEAGKLLHGSVFSKRFFGSFQWEEFACGCGAAFVNIAVTYPIY 75

Human    36 TAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLY 100
            ....|..:.|.   |: .:|.||           :|.||...||.|::..|.::....|:..|::
  Fly    76 KMIFRQMLHGV---PI-TSAFAQ-----------LRHEGLGFLYRGMLPPLAQKTISLSIMFGVF 125

Human   101 DSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKT 165
            |..:::..:.......|:::||....|: |.::..|.:.|:...   |.:...:.:.:|.||::.
  Fly   126 DGTRRYLVEDYRLNDYGAKVLAAVVAGS-AESILLPFERVQTLL---ADSKFHQHFSNTQNAFRY 186

Human   166 IAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTV 230
            :....|:|.|::|..|...||.:.|....|..:.....|.|...::......|.:....|...:.
  Fly   187 VVSHHGYRELYRGLEPVFWRNGLSNALFFVLREEASVRLPKRKSVSTRTVQEFIAGAVIGASIST 251

Human   231 IASPVDVVKTRYMNSALGQYSSAGHCALTMLQKEGPRA---FYKGFMP-----SFLRLGSWNVVM 287
            |..|::|:|.. :.|.:||.|.....|...:..|..|.   ||:| .|     ||:   ||. :|
  Fly   252 IFYPLNVIKVS-LQSEMGQRSEGSWQACKRIYVERDRRIGNFYRG-CPFNTGRSFI---SWG-IM 310

Human   288 FVTYEQLKRAL 298
            ...||.||:.:
  Fly   311 NTAYENLKKLM 321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UCP2	NP_003346.2	Mito_carr	10..111	CDD:395101	24/134 (18%)
		Solcar 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	11..106		23/128 (18%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	16..63		12/55 (22%)
		transmembrane domain	17..34		5/25 (20%)
		transmembrane domain	78..100		6/21 (29%)
		Mito_carr	112..206	CDD:395101	21/93 (23%)
		Solcar 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	114..203		20/88 (23%)
		transmembrane domain	120..137		4/16 (25%)
		transmembrane domain	174..197		7/22 (32%)
		Solcar 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	212..297		26/92 (28%)
		transmembrane domain	216..235		3/18 (17%)
		Mito_carr	217..299	CDD:395101	26/90 (29%)
		purine nucleotide binding domain	264..273		4/11 (36%)
		transmembrane domain	269..291		9/26 (35%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	278..285		2/6 (33%)
CG7943	NP_651766.1	Mito_carr	54..136	CDD:395101	20/96 (21%)
		Mito_carr	141..229	CDD:395101	22/91 (24%)
		Mito_carr	235..322	CDD:395101	26/93 (28%)