Protein Alignment UCP2 and GC2

DIOPT Version :10

• Sequence 1: NP_003346.2
• Gene: UCP2 / 7351
• HGNCID: 12518
• Length: 309
• Species: Homo sapiens
• Sequence 2: NP_731657.2
• Gene: GC2 / 41449
• FlyBaseID: FBgn0037970
• Length: 319
• Species: Drosophila melanogaster
• Alignment Length: 27
• Identity: 8/27 - (29%)
• Similarity: 17/27 - (62%)
• Gaps: 3/27 - (11%)

Human    56 EKEKIVWVRFENADLNDTSRNLEFHEL 82
            |:::::..|:..   |||:.::..|||
  Fly   101 ERDELLRTRYRP---NDTALSIGDHEL 124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UCP2	NP_003346.2	Mito_carr	10..111	CDD:395101	8/27 (30%)
		Solcar 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	11..106		8/27 (30%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	16..63		1/6 (17%)
		transmembrane domain	17..34
		transmembrane domain	78..100		3/5 (60%)
		Mito_carr	112..206	CDD:395101
		Solcar 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	114..203
		transmembrane domain	120..137
		transmembrane domain	174..197
		Solcar 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	212..297
		transmembrane domain	216..235
		Mito_carr	217..299	CDD:395101
		purine nucleotide binding domain	264..273
		transmembrane domain	269..291
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	278..285
GC2	NP_731657.2	Mito_carr	16..106	CDD:395101	1/4 (25%)
		Mito_carr	123..203	CDD:395101	2/2 (100%)
		Mito_carr	228..302	CDD:395101