Protein Alignment UCP2 and SCaMC

DIOPT Version :10

• Sequence 1: NP_003346.2
• Gene: UCP2 / 7351
• HGNCID: 12518
• Length: 309
• Species: Homo sapiens
• Sequence 2: NP_729802.1
• Gene: SCaMC / 39415
• FlyBaseID: FBgn0052103
• Length: 583
• Species: Drosophila melanogaster
• Alignment Length: 330
• Identity: 78/330 - (23%)
• Similarity: 133/330 - (40%)
• Gaps: 60/330 - (18%)

Human     8 DVPPTATVK----------FLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGV 62
            :||...|.|          .:..|.|..::...|.|||..||.||:|            .|..|:
  Fly   270 NVPDDFTQKEMQTGLWWRHLVAGGIAGAVSRTCTAPLDRIKVYLQVQ------------TQRMGI 322

Human    63 MGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFY--TKGSEHASIGSRLLAGST 125
            ...:..|:...|.||::.|....:.:.....:.:...|:.:|:..  ..||...||..|..||:.
  Fly   323 SECMHIMLNEGGSRSMWRGNGINVLKIAPETAFKFAAYEQMKRLIRGDDGSRQMSIVERFYAGAA 387

Human   126 TGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVN 190
            .|.::..:..|.:|:|.|. |..|.|   :|....:|...|.::||.|..::|..||:.......
  Fly   388 AGGISQTIIYPMEVLKTRL-ALRRTG---QYAGIADAAVKIYKQEGVRSFYRGYVPNILGILPYA 448

Human   191 CAELVTYDLIKDALLKANLMTDDLP-------CHFTSAFGAGFCTTVIASPVDVVKTRYMNSALG 248
            ..:|..|:.:|...: ||...::.|       |..||:.....|    :.|:.:|:||....|..
  Fly   449 GIDLAVYETLKRRYI-ANHDNNEQPSFLVLLACGSTSSTLGQLC----SYPLALVRTRLQAQAAE 508

Human   249 QYSS---------------AGHCALT-----MLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQ 293
            ..::               :|...:|     ::::||....|:|..|:||::.....:.:|.||.
  Fly   509 TIANQKRKTQIPLKSSDAHSGEETMTGLFRKIVRQEGLTGLYRGITPNFLKVLPAVSISYVVYEY 573

Human   294 LKRAL 298
            ..|||
  Fly   574 TSRAL 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UCP2	NP_003346.2	Mito_carr	10..111	CDD:395101	23/112 (21%)
		Solcar 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	11..106		22/104 (21%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	16..63		14/56 (25%)
		transmembrane domain	17..34		3/16 (19%)
		transmembrane domain	78..100		1/21 (5%)
		Mito_carr	112..206	CDD:395101	25/93 (27%)
		Solcar 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	114..203		25/88 (28%)
		transmembrane domain	120..137		3/16 (19%)
		transmembrane domain	174..197		4/22 (18%)
		Solcar 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	212..297		22/111 (20%)
		transmembrane domain	216..235		4/18 (22%)
		Mito_carr	217..299	CDD:395101	23/102 (23%)
		purine nucleotide binding domain	264..273		3/8 (38%)
		transmembrane domain	269..291		6/21 (29%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	278..285		1/6 (17%)
SCaMC	NP_729802.1	FRQ1	114..242	CDD:444056
		PTZ00169	290..559	CDD:240302	67/289 (23%)