Protein Alignment UCP2 and Bmcp

DIOPT Version :10

• Sequence 1: NP_003346.2
• Gene: UCP2 / 7351
• HGNCID: 12518
• Length: 309
• Species: Homo sapiens
• Sequence 2: NP_648501.1
• Gene: Bmcp / 39322
• FlyBaseID: FBgn0036199
• Length: 303
• Species: Drosophila melanogaster
• Alignment Length: 303
• Identity: 102/303 - (33%)
• Similarity: 167/303 - (55%)
• Gaps: 33/303 - (10%)

Human    17 FLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNG 81
            |:..|.|:..|:..|||:||.|.||||||:...  ::.:..:|||:....:.:.|.||.|:||:|
  Fly    10 FVYGGVASITAEFGTFPIDTTKTRLQIQGQKID--QSFSQLRYRGMTDAFVKISREEGLRALYSG 72

Human    82 LVAGLQRQMSFASVRIGLYDSVKQFYTK--------GSEHASIGSRLLAGSTTGALAVAVAQPTD 138
            :...:.||.::.:::.|.|.::|:...:        |||.  :.|.:|..:..||::.|:|.|||
  Fly    73 IWPAVLRQATYGTIKFGTYYTLKKLANERGLLINEDGSER--VWSNILCAAAAGAISSAIANPTD 135

Human   139 VVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKDA 203
            |:|||.|..    |..:::..:..:..|.:.||.||||:|..|...|..::...||..||..|..
  Fly   136 VLKVRMQVH----GKGQHKGLLGCFGEIYKYEGVRGLWRGVGPTAQRAVVIASVELPVYDFCKLQ 196

Human   204 LLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMN---------------SALGQYSSA 253
            |:  |...|.:..||.|:|.|...:.:.::|:||::||.||               :....||.:
  Fly   197 LM--NAFGDHVGNHFISSFIASLGSAIASTPIDVIRTRLMNQRPVSITMNGVVTAAATPKLYSGS 259

Human   254 GHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296
            ..||:..::.||..|.||||:|:::|:|.||::.|:||||||:
  Fly   260 LDCAVQTIRNEGLPALYKGFIPTWVRMGPWNIIFFITYEQLKK 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UCP2	NP_003346.2	Mito_carr	10..111	CDD:395101	31/101 (31%)
		Solcar 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	11..106		31/88 (35%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	16..63		19/45 (42%)
		transmembrane domain	17..34		6/16 (38%)
		transmembrane domain	78..100		6/21 (29%)
		Mito_carr	112..206	CDD:395101	32/93 (34%)
		Solcar 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	114..203		30/88 (34%)
		transmembrane domain	120..137		5/16 (31%)
		transmembrane domain	174..197		8/22 (36%)
		Solcar 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	212..297		36/100 (36%)
		transmembrane domain	216..235		5/18 (28%)
		Mito_carr	217..299	CDD:395101	35/95 (37%)
		purine nucleotide binding domain	264..273		5/8 (63%)
		transmembrane domain	269..291		10/21 (48%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	278..285		3/6 (50%)
Bmcp	NP_648501.1	Mito_carr	7..97	CDD:395101	31/88 (35%)
		Mito_carr	<132..199	CDD:395101	25/72 (35%)
		Mito_carr	204..303	CDD:395101	35/99 (35%)